Table 2 HLA Alleles Associated with Persistent Cervical hrHPV Infection.
Allele | Frequency Cases | Frequency Controls | Odds Ratio (95% CI) | P-value | FDR-Adjusted P-value |
|---|---|---|---|---|---|
Discovery in ACCME Cohort | |||||
DRB1*15:03 | 0.161 | 0.199 | 0.77 (0.66–0.89) | 7.20 × 10−04 | 0.006 |
DRB1*13:02 | 0.074 | 0.054 | 1.45 (1.17–1.79) | 5.85 × 10−04 | 0.006 |
DQB1*05:02 | 0.056 | 0.039 | 1.48 (1.17–1.89) | 0.001 | 0.015 |
DRB1*03:01 | 0.099 | 0.076 | 1.29 (1.07–1.56) | 0.007 | 0.041 |
DQB1*06:02 | 0.241 | 0.275 | 0.84 (0.74–0.96) | 0.012 | 0.068 |
DQB1*02:01 | 0.142 | 0.119 | 1.21 (1.03–1.43) | 0.017 | 0.068 |
DQB1*02:02 | 0.050 | 0.066 | 0.76 (0.59–0.98) | 0.037 | 0.111 |
Replication in PACS Cohort | |||||
DRB1*15:03 | 0.156 | 0.184 | 0.84 (0.48–1.46) | 0.543 | 0.611 |
DRB1*13:02 | 0.107 | 0.059 | 2.35 (1.07–5.16) | 0.031 | 0.142 |
DQB1*05:02 | - | - | - | - | - |
DRB1*03:01 | 0.156 | 0.071 | 2.37 (1.21–4.65) | 0.011 | 0.094 |
DQB1*06:02 | 0.264 | 0.263 | 0.97 (0.60–1.55) | 0.909 | 0.909 |
DQB1*02:01 | 0.142 | 0.119 | 2.10 (1.08–4.09) | 0.020 | 0.061 |
DQB1*02:02 | 0.088 | 0.075 | 1.16 (0.54–2.52) | 0.690 | 0.828 |
Combined ACCME and PACS Cohorts | |||||
DRB1*15:03 | 0.1592 | 0.2004 | 0.75 (0.65–0.87) | 1.73E-04 | 0.0017 |
DRB1*13:02 | 0.0743 | 0.0544 | 1.46 (1.18–1.79) | 3.84E-04 | 0.0019 |
DRB1*03:01 | 0.1003 | 0.0765 | 1.30 (1.08–1.56) | 0.0047 | 0.0155 |
DQB1*06:02 | 0.2405 | 0.2756 | 0.84 (0.74–0.95) | 0.0078 | 0.0468 |
DQB1*02:01 | 0.141 | 0.1199 | 1.20 (1.03–1.41) | 0.0195 | 0.0584 |
DQB1*02:02 | 0.0512 | 0.0668 | 0.78 (0.61–0.99) | 0.0481 | 0.0962 |
DQA1*05:01 | 0.1157 | 0.0931 | 1.22 (1.03–1.44) | 0.0174 | 0.1046 |
B*15:03 | 0.068 | 0.0547 | 1.27 (1.02–1.58) | 0.0288 | 0.1568 |
B*58:02 | 0.0414 | 0.0569 | 0.74 (0.57–0.97) | 0.0349 | 0.1568 |
C*06:02 | 0.0673 | 0.0832 | 0.81 (0.65–1.01) | 0.0651 | 0.228 |
C*07:01 | 0.1073 | 0.1283 | 0.83 (0.70–0.99) | 0.0467 | 0.228 |
