Fig. 3: Neurocognitive phenotype of HTT intermediate alleles carriers. | European Journal of Human Genetics

Fig. 3: Neurocognitive phenotype of HTT intermediate alleles carriers.

From: Somatic CAG repeat instability in intermediate alleles of the HTT gene and its potential association with a clinical phenotype

Fig. 3

The graphs summarize the clinical characteristics of symptomatic cases represented as, (a) Onset of symptoms in intermediate (green, n = 49), reduced-penetrance (orange, n = 13) and full-penetrance (blue, n = 229) alleles carriers by the number of CAG repeats. The purple lines indicate the prediction of age at onset by Langbehn et al. [50], average (solid line) ± SD (dotted lines). (b) Venn diagram depicting the breakdown of neurocognitive signs into motor, cognitive and behavioural in 82 HTT intermediate allele carriers.

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