Table 1 Linear regression results showing the main effects of the number of CAGs in the inherited allele and age at sampling on the ratio of CAG expansions for alleles ranging from 10 to 50 CAGs, categorised into normal, intermediate, reduced-penetrance and full-penetrance alleles.

Allele type (CAG range)	n	Min	Max	Ratio of CAG expansions^a
				Main effects							Interaction effects
				CAG			Age			R²	Interaction effects
				β-coefficient	CI (95%)	p value	β-coefficient	CI (95%)	p value	R²	p value
Normal (10-27)	47	0.004	0.024	0.001	0.001, 0.002	<0.001	−0.00002	−0.0001, 0.0001	0.719	0.324	0.736
Intermediate (27-35)	135	0.020	0.091	0.004	0.004, 0.005	<0.001	0.0001	0.0001, 0.0002	0.001	0.646	0.010
Reduced-penetrance (36-39)	37	0.063	0.878	0.047	0.014, 0.079	0.006	0.003	0.001, 0.005	0.009	0.332	0.200
Full penetrance (40-50)	74	0.148	1787	0.125	0.107, 0.143	<0.001	0.011	0.007, 0.015	<0.001	0.742	0.031

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