Table 2 Demographics and clinical characteristics amongst 2PV carriers by variant types.
From: Multi-locus inherited neoplasia alleles syndromes in cancer: implications for clinical practice
Dominant-Dominant (N = 324) | Dominant-Recessive (N = 67) | Recessive-Recessive (N = 5) | p-value | |
|---|---|---|---|---|
Sex | 0.227 | |||
Female | 266 (82.1%) | 58 (86.6%) | 3 (60.0%) | |
Male | 58 (17.9%) | 9 (13.4%) | 2 (40.0%) | |
Number of cancers | 0.051 | |||
0 | 18 (5.6%) | 4 (6.0%) | 2 (40.0%) | |
1 | 196 (60.5%) | 47 (70.1%) | 2 (40.0%) | |
≥2 | 110 (34.0%) | 16 (23.9%) | 1 (20.0%) | |
First age of cancer diagnosis | 0.783# | |||
Mean(SD) | 40.9 (14.5) | 41.0 (12.5) | 38.0 (8.9) | |
Median (IQR) | 40.5 (33.0, 50.0) | 40.0 (32.5, 48.5) | 36.0 (34.0, 40.0) | |
Range | 0.0–87.0 | 1.0–70.0 | 28.0–52.0 | |
Early onset of cancer | 0.367 | |||
Yes | 78 (24.1%) | 20 (29.9%) | 2 (40.0%) | |
No | 246 (75.9%) | 47 (70.1%) | 3 (60.0%) | |
Presence of atypical phenotypes | 0.022 | |||
Yes | 43 (13.3%) | 12 (17.9%) | 3 (60.0%) | |
No | 281 (86.7%) | 55 (82.1%) | 2 (40.0%) | |
Number of PV expressed phenotypically | <0.001 | |||
0 | 11 (3.4%) | 7 (10.4%) | 2 (40.0%) | |
1 | 67 (20.7%) | 47 (70.1%) | 1 (20.0%) | |
2 | 246 (75.9%) | 13 (19.4%) | 2 (40.0%) | |
