Table 3 Genes most strongly associated with epithelial ovarian cancer based on analysis of combined non-UKB and UKB data.

From: Exome sequencing identifies HELB as a novel susceptibility gene for non-mucinous, non-high-grade-serous epithelial ovarian cancer

Case type

Gene

Minor allele freq

Odds ratio

(95% CI)

P-value

FDR

BFDP

HGSOC

BRCA2

0.0036

12

(8.4 - 18)

1.7 × 10−38

8.1 × 10−35

4.4 × 10−33

HGSOC

BRCA1

0.0010

40

(22 - 70)

4.8  × 10−36

1.2 × 10−32

1.5 × 10−29

HGSOC

BRIP1

0.0011

10

(5.4 - 20)

4.3  × 10−12

3.6 × 10−9

2.3 × 10−7

HGSOC

RAD51C

0.00057

12

(4.7 - 28)

8.7  × 10−8

5.3 × 10−5

0.0028

NHGSOC

MSH6

0.0013

11

(4.4 - 26)

1.6  × 10−7

8.7 × 10−5

0.0045

HGSOC

RAD51D

0.00043

13

(4.5 - 37)

2.0  × 10−6

9.1 × 10−4

0.053

NHGSOC

OR2T35

0.00072

15

(4.4 - 48)

1.2  × 10−5

0.0048

0.23

NHGSOC

HELB

0.00093

9.6

(3.3 - 28)

3.0  × 10−5

0.011

0.30

NHGSOC

MYO1A

0.0024

9.1

(3.1 - 27)

6.0  × 10−5

0.020

0.43

NHGSOC

GABRP

0.00072

78

(7.9 - 780)

2.0 × 10−4

0.060

0.92

HGSOC

MIG1A

0.00022

15

(3.5 - 65)

2.6 × 10−4

0.072

0.80

HGSOC

PALB2

0.0017

3.6

(1.8 - 7.4)

3.2 × 10-4

0.081

0.65

NHGSOC

NBN

0.0015

7

(2.4 - 21)

4.4 × 10−4

0.10

0.77

HGSOC

STARD6

0.00050

7

(2.3 - 21)

4.8 × 10−4

0.10

0.78

NHGSOC

KIR3DL1

0.00014

32

(4.5 - 230)

5.5 × 10−4

0.11

0.93

NMOC

NENF

0.00050

6.5

(2.2 - 19)

5.5 × 10−4

0.11

0.79

NHGSOC

HPSE

0.001

7.8

(2.4 - 25)

6.0 × 10−4

0.11

0.82

HGSOC

OR4A47

0.00036

8.5

(2.5 - 29)

6.5 × 10−4

0.11

0.84

HGSOC

SH3BGRL

0.00044

15

(3.2 - 73)

6.3 × 10−4

0.11

0.89

NHGSOC

SHMT1

0.0013

10

(2.6 - 42)

0.001

0.17

0.90

NHGSOC

SALL2

0.00022

20

(3.3 - 130)

0.0012

0.18

0.94

NHGSOC

FASTKD5

0.00044

33

(3.9 - 270)

0.0013

0.19

0.96

NMOC

PLEKHG5

0.0019

3.9

(1.7 - 9)

0.0014

0.20

0.87

HGSOC

DQX1

0.0017

3.5

(1.6 - 7.6)

0.0017

0.20

0.88

NHGSOC

FAM71F1

0.00036

16

(2.9 - 87)

0.0015

0.20

0.94

NHGSOC

LIFR

0.0011

11

(2.4 - 46)

0.0018

0.20

0.93

NMOC

LIPT1

0.00050

4.9

(1.8 - 13)

0.0017

0.20

0.89

NHGSOC

LTBP2

0.00050

12

(2.6 - 61)

0.0017

0.20

0.94

NHGSOC

MMAA

0.0011

7.5

(2.2 - 26)

0.0016

0.20

0.91

NHGSOC

POLR2A

0.002

5.4

(1.9 - 16)

0.0018

0.20

0.90

NHGSOC

CD302

0.00022

48

(4.2 - 560)

0.0019

0.20

0.97

  1. FDR Benjamini-Hochberg false discovery rate, BFDP Bayes false discovery probability, HGSOC high-grade serous ovarian cancer, NMOC non-mucinous epithelial ovarian cancer, NHGSOC non-high-grade serous ovarian cancer (non-mucinous).
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