Table 3 Variants (MAF > 0.005) in Mendelian Traits genes with genome-wide significant associations with age-related hearing loss phenotype.

From: Mendelian non-syndromic and syndromic hearing loss genes contribute to presbycusis

  1. Variants highlighted in gray were previously found to be associated with ARHL.
  2. ARHL age-related hearing loss, B Beta, CHR chromosome, DFNA Autosomal dominant non-syndromic hearing loss locus, DFNB Autosomal recessive non-syndromic hearing loss locus, *EAF effect allele frequency for H-noise cases and controls (N = 392,110), the allele frequencies for the other populations were very similar with a slight change due to differences in sample size, HL Hearing loss, MAF minor allele frequency, P P-value, SE standard error.
  3. Variants with MAF > 0.005 in Mendelian hearing loss genes that are *genome-wide significant (p  <  5 × 10−8) or **significant after a Bonferroni correction for testing hearing aid (H-aid), hearing difficulty (H-diff), hearing difficulty with background noise (H-noise) and the combined hearing trait (H-both) (p < 1.25 × 10−8) in the univariate analysis of the white-European individuals from the UK Biobank.
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