Table 1 PICOS criteria for study selection.
From: A systematic review of the implications of lipocalin-2 expression in periodontal disease
Population (P): | Subjects ≥18 years old with gingivitis and/or periodontitis. Due to the heterogeneity of the criteria and the definitions of periodontitis any current and past classifications defined and diagnosed by authors were taken into consideration. |
Intervention (I): | Screening tests and studies based on any kind of periodontal therapy. |
Control (C): | Periodontally and systemically healthy individuals. |
Outcome (O): | Changes in LCN-2 concentrations and at least 3 periodontal health parameters: bleeding on probing, BOP (%); probing depth, PD (mm); clinical attachment loss, CAL (mm); plaque index, PI; and gingival index. |
Studies (S): | Observational studies: cohort, case-control, cross-sectional, prospective. Experimental studies: Randomized controlled trials Published from 2000 to 2024. |
