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Surgical periodontal therapy for the management of intrabony/furcation defects with and without topically delivered Alendronate - a systematic review and meta-analysis

Evidence-Based Dentistry volume 26, pages 156–157 (2025)Cite this article

Subjects

Abstract

Objective

Alendronate (ALN) are pyrophosphates which prevent bone resorption and aid in periodontal regeneration. The present review aimed to evaluate the success of surgical periodontal therapy in the management of intrabony/ furcation defects with and without topical application of ALN.

Method

Using combinations of different search terms, the authors searched the standard electronic databases for randomised controlled trials. Version 2 of the Cochrane risk of bias tool for randomised trials was used for quality appraisal. The random-effects model was used for the statistical analysis of estimated effect sizes. The overall quality of evidence was assessed using GRADEpro GDT software.

Results

Nine studies satisfying all inclusion criteria were selected for qualitative analysis, and six studies with homogeneous data were selected for quantitative analysis. The overall risk of bias had “low” concerns in one study, “some” concerns in four studies, and “high” concerns in four studies. The pooled analysis showed that the experimental group showed a significant reduction in periodontal probing depth(PPD) and defect depth(DD) with a standard mean difference(SDM) of 1.06 mm (95% CI, 0.77–1.34; P < 0.00001; I2 = 0%) and 1.10 mm (95% CI, 0.65–1.54; P < 0.00001; I2 = 56%) respectively, significant improvement in the clinical attachment level (CAL) with SDM of 1.03 mm (95% CI, 0.42-1.64; P = 0.0009; I2 = 76%).

Conclusions

The topical application of ALN has been shown to enhance the effectiveness of surgical periodontal therapy by reducing the PPD and DD and increasing the CAL; however, the certainty of evidence remains very low to low.

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Data availability

The data supporting this article can be made available by the corresponding author upon request.

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Authors and Affiliations

  1. Department Of Dentistry, All India Institute Of Medical Sciences, Jodhpur, India

    A. Rizwan Ali, Pravin Kumar, Karishma Pathak, Ankita Chugh & Kirti Chaudhry

  2. Department Of Dentistry, All India Institute Of Medical Sciences, Rajkot, India

    Arun Kumar Patnana

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  1. A. Rizwan Ali
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Contributions

Pravin Kumar formulated the concept and design. Arun Kumar Patnana and A Rizwan Ali conducted literature search, data extraction from the included articles. Pravin Kumar, Arun Kumar Patnana, A Rizwan Ali and Karishma Pathak were involved in the analysis and interpretation of the data. Pravin Kumar, Arun Kumar Patnana, Ankita Chugh and Kirti Chaudhry drafted the manuscript. Pravin Kumar critically revised the manuscript and approved the final version to be published.

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Correspondence to A. Rizwan Ali.

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Ali, A.R., Patnana, A.K., Kumar, P. et al. Surgical periodontal therapy for the management of intrabony/furcation defects with and without topically delivered Alendronate - a systematic review and meta-analysis. Evid Based Dent 26, 156–157 (2025). https://doi.org/10.1038/s41432-025-01165-0

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