Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Bond strength of flowable dental composites in the cementation of indirect restorations: a systematic review and meta-analysis

Abstract

Aim

This systematic review evaluated experimental evidence on how incorporating flowable dental composites affects the bond strength of dental cementation.

Material And Methods

This systematic review, following PRISMA guidelines, assessed in vitro studies (2003–2025) on the effect of flowable composites on cementation bond strength using a comprehensive database search, QUIN Tool for bias assessment, Begg’s and Egger’s tests for publication bias, and random-effects meta-analysis with SMD and I² statistics.

Results

This systematic review included eight in vitro studies published between 2003 and 2025. The meta-analysis found no statistically significant differences among the various bond strength test methods. Although the shear bond strength (SBS) test demonstrated a significant effect, the high heterogeneity among studies limits the reliability of this result. Etchable ceramics showed favourable effect sizes, but again, the high heterogeneity reduces the certainty of this finding. No significant difference was observed between self-etch and self-adhesive resin cements; however, self-etch resin cements tended to perform better in terms of bond strength. Nevertheless, the substantial heterogeneity in both adhesive groups indicates notable variability across studies. For the dual-cured group, a statistically significant standardized mean difference was observed, suggesting a positive effect of the dual-cured luting cement compared to the light-cured luting cement.

Conclusion

Flowable dental composites generally perform comparably to conventional resin cements, with dual-cured and self-etch resin cements showing a tendency toward improved bond strength. However, variability across studies limits the certainty of these results. Further standardized in vitro studies are needed to confirm these findings and guide clinical application.

This is a preview of subscription content, access via your institution

Access options

Buy this article

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

Data availability

The dataset used in the present study is available from the corresponding author upon reasonable request.

References

  1. Özcan M, Vallittu PK. Effect of surface conditioning methods on the bond strength of luting cement to ceramics. Dent Mater. 2003;19:725–31.

    Article  PubMed  Google Scholar 

  2. Ferracane JL. Resin composite—State of the art. Dent Mater. 2011;27:29–38.

    Article  CAS  PubMed  Google Scholar 

  3. Francois P, Attal J, Fasham T, Troizier-Cheyne M, Gouze H, Abdel-Gawad S, et al. Flexural properties, wear resistance, and microstructural analysis of highly filled flowable resin composites. Oper. Dent. 2024;49:597–607.

    Article  CAS  PubMed  Google Scholar 

  4. Al Sunbul H, Silikas N, Watts DC. Polymerization shrinkage kinetics and shrinkage-stress in dental resin-composites. Dent Mater. 2016;32:998–1006.

    Article  CAS  PubMed  Google Scholar 

  5. Archegas LRP, Freire A, Vieira S, de Menezes Caldas DB, Souza EM. Colour stability and opacity of resin cements and flowable composites for ceramic veneer luting after accelerated ageing. J Dent. 2011;39:804–10.

    Article  CAS  PubMed  Google Scholar 

  6. Pereira JSdC, Reis JA, Martins F, Maurício P, Fuentes MV. The effect of feldspathic thickness on fluorescence of a variety of resin cements and flowable composites. Appl Sci. 2022;12:6535.

    Article  CAS  Google Scholar 

  7. Kumar R, Ranjan N, Sidhu RS. Role of fillers and various sustainable innovations in the use of filler material for the preparation of composites. Green Compos Manuf: Sustain Approach. 2024;19:79.

    Google Scholar 

  8. Barceleiro MDO, Miranda M, Dias K, Sekito T. Shear bond strength of porcelain laminate veneer bonded with flowable composite. Oper Dent. 2003;28:423–8.

    PubMed  Google Scholar 

  9. Braga RR, Ballester RY, Ferracane JL. Factors involved in the development of polymerization shrinkage stress in resin-composites: a systematic review. Dent Mater. 2005;21:962–70.

    Article  CAS  PubMed  Google Scholar 

  10. Dikici B, Türkeş Başaran E, Can E. Does the type of resin luting material affect the bonding of CAD/CAM materials to Dentin?. Dent J. 2025;13:41.

    Article  Google Scholar 

  11. Elnagar RK, Eltoukhy RI, Mahmoud SH. Tensile bond strength of machinable ceramics bonded to dentin using pre-heated resin composite, flowable composite and resin cement: A laboratory trial. Mansoura J Dent. 2024;11:8.

    Google Scholar 

  12. Grangeiro MTV, da Silva, Rodrigues C, Rossi NR, Souza KB, de Melo RM, Bottino MA. Preheated composite as an alternative for bonding feldspathic and hybrid ceramics: a microshear bond strength study. J Adhes Dent. 2023;25:b4279775.

    PubMed  PubMed Central  Google Scholar 

  13. Hassanien EEY, Tolba ZO. Flowable composite as an alternative to adhesive resin cement in bonding hybrid CAD/CAM materials: In-vitro study of micro-shear bond strength. BDJ open. 2024;10:66.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Tribst JPM, Etoeharnowo L, Tadros M, Feilzer AJ, Werner A, Kleverlaan CJ, et al. The influence of pre-heating the restoration and luting agent on the flexural strength of indirect ceramic and composite restorations. Biomater Investig Dent. 2023;10:2279066.

    PubMed  PubMed Central  Google Scholar 

  15. Castro-Ramirez LC, Ladera-Castañeda MI, Cachay-Criado HR, Alvino-Vales MI, López-Gurreonero C, Cervantes-Ganoza LA, et al. Comparative evaluation of microtensile bond strength in three different dentin luting agents: an in vitro study. J Int Soc Prev Commun Dentistry. 2023.

  16. Sheth VH, Shah NP, Jain R, Bhanushali N, Bhatnagar V. Development and validation of a risk-of-bias tool for assessing in vitro studies conducted in dentistry: The QUIN. J Prosthet Dent. 2024;131:1038–42.

    Article  CAS  PubMed  Google Scholar 

  17. Chandler J, Cumpston M, Li T, Page MJ, Welch V Cochrane handbook for systematic reviews of interventions. Hoboken: Wiley. 2019;4.

  18. Staněk J, Riad A, Le A, Bernát M, Hammal M, Azar B. Survival of prosthodontic restorations luted with resin-based versus composite-based cements: Retrospective cohort study. Materials. 2022;15:312.

    Article  PubMed  PubMed Central  Google Scholar 

  19. El-Askary F, Tadros NM, Hassanien A, Aboalazm E, Kamel MA, Özcan M. Is there a correlation between physical properties and film thickness of dual-and photo-polymerized resin cements and CAD/CAM-dentin micro-tensile bond strength?. J Adhes Sci Technol. 2024;38:4116–36.

    Article  CAS  Google Scholar 

  20. Mutlu A, Atay A, Çal E. Bonding effectiveness of contemporary materials in luting glass-ceramic to dentine: an in vitro study. J Adv Oral Res. 2021;12:103–11.

    Article  Google Scholar 

  21. Günal-Abduljalil B, Önöral Ö, Ongun S. Micro-shear bond strengths of resin-matrix ceramics subjected to different surface conditioning strategies with or without coupling agent application. J Adv Prosthodont. 2021;13:180.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Erickson RL, Barkmeier WW, Latta MA. The role of etching in bonding to enamel: a comparison of self-etching and etch-and-rinse adhesive systems. Dent Mater. 2009;25:1459–67.

    Article  CAS  PubMed  Google Scholar 

  23. Fornazari IA, Brum RT, Rached RN, de Souza EM. Reliability and correlation between microshear and microtensile bond strength tests of composite repairs. J Mech Behav Biomed Mater. 2020;103:103607.

    Article  CAS  PubMed  Google Scholar 

  24. Miotti L, Follak A, Montagner A, Pozzobon R, Da Silveira B, Susin A. Is conventional resin cement adhesive performance to dentin better than self-adhesive? A systematic review and meta-analysis of laboratory studies. Oper Dent. 2020;45:484–95.

    Article  CAS  PubMed  Google Scholar 

  25. Muñoz MA, Baggio R, Mendes YBE, Gomes GM, Luque-Martinez I, Loguercio AD, et al. The effect of the loading method and cross-head speed on resin–dentin microshear bond strength. Int J Adhes Adhes. 2014;50:136–41.

    Article  Google Scholar 

  26. Ruse N, Sadoun M. Resin-composite blocks for dental CAD/CAM applications. J Dent Res. 2014;93:1232–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Riesgo BVP, da Silva Rodrigues C, do Nascimento LP, May LG. Effect of hydrofluoric acid concentration and etching time on the adhesive and mechanical behavior of glass-ceramics: A systematic review and meta-analysis. Int J Adhes Adhes. 2023;121:103303.

    Article  CAS  Google Scholar 

  28. Ria A, Ibrahim H. Adhesion to Zirconia: Factors affect bonding to Zirconia. ERU Res J. 2025;4:2190–209.

    Article  Google Scholar 

Download references

Acknowledgements

We appreciate all the people who helped us in providing this manuscript.

Author information

Authors and Affiliations

Authors

Contributions

All authors contributed substantially to the conception and design of the study. A.I. and B.O. conducted the systematic literature search, study selection, and data extraction. S.H.& A.I. performed the statistical analysis and contributed to data interpretation. A.I. drafted the manuscript, and all authors critically revised it for important intellectual content. All authors read and approved the final version of the manuscript.

Corresponding author

Correspondence to Armin Izadpanah.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Omidi, B.R., Heidari, S. & Izadpanah, A. Bond strength of flowable dental composites in the cementation of indirect restorations: a systematic review and meta-analysis. Evid Based Dent 26, 178–179 (2025). https://doi.org/10.1038/s41432-025-01187-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Version of record:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41432-025-01187-8

Search

Quick links