Abstract
Purpose
The purpose of our study was to assess changes in peripapillary retinal nerve fiber layer (RNFL) thickness after orbital wall decompression in eyes with dysthyroid optic neuropathy (DON).
Methods
We analyzed peripapillary optical coherence tomography (OCT) images (Cirrus HD-OCT) from controls and patients with DON before and 1 and 6 months after orbital wall decompression.
Results
There was no significant difference in mean preoperative peripapillary retinal nerve fiber layer thickness between eyes with DON and controls. The superior and inferior peripapillary RNFL thickness decreased significantly 1 month after decompression surgery compared to preoperative values (p = 0.043 and p = 0.022, respectively). The global average, superior, temporal, and inferior peripapillary RNFL thickness decreased significantly 6 months after decompression surgery compared to preoperative values (p = 0.015, p = 0.028, p = 0.009, and p = 0.006, respectively). Patients with greater preoperative inferior peripapillary RNFL thickness tended to have better postoperative visual acuity at the last visit (p = 0.024, OR = 0.926).
Conclusions
Our data revealed a significant decrease in peripapillary RNFL thickness postoperatively after orbital decompression surgery in patients with DON. We also found that greater preoperative inferior peripapillary RNFL thickness was associated with better visual outcomes. We suggest that RNFL thickness can be used as a prognostic factor for DON before decompression surgery.
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Author contributions
The following authors were involved; study design (Y.D.K.); conduction of the study (K.A.P., Y.D.K.); data collection and management (K.A.P., Y.D.K.); data analysis and interpretation (K.A.P.); drafting the manuscript (K.A.P.); and the review and final approval of the manuscript (K.I.W., Y.D.K.). This study followed the tenets of the Declaration of Helsinki. This study was approved by the Institutional Review Board of Samsung Medical Center.
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Park, KA., Kim, YD. & Woo, K.I. Changes in optical coherence tomography measurements after orbital wall decompression in dysthyroid optic neuropathy. Eye 32, 1123–1129 (2018). https://doi.org/10.1038/s41433-018-0051-1
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DOI: https://doi.org/10.1038/s41433-018-0051-1
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