Abstract
Purpose
To investigate whether there is any effect of age on bleb morphology and surgical success after trabeculectomy with adjunctive Mitomycin C (MMC).
Methods
A total 143 eyes of 123 patients were divided into two groups: group 1 ( ≤ 60 years old, n = 85) and group 2 ( > 60 years old, n = 58). Kaplan–Meier survival curve analysis was used to assess long-term surgical success according to “complete success” (intraocular pressure (IOP) reduction ≥ 30% without medications) and “qualified success” criteria (IOP reduction ≥ 30%, with or without medications) between the two groups. Cox proportional hazard models were used to examine the factors associated with surgical success. Bleb morphology was evaluated by height, extent and vascularity at postoperative 1 month, 3 months, 6 months, and 12 months.
Results
The younger-age group (group 1) showed significantly better results, in terms of both complete success and qualified success, than did the older-age group (group 2) (p < 0.001 and p = 0.01, respectively). Age and preoperative anti-glaucoma medications were the factors related to complete success (p = 0.001). Also, there were significant differences in height, extent and vascularity of bleb between the two groups (p = 0.038, p = 0.002 and p = 0.006, respectively).
Conclusion
The long-term surgical outcome after trabeculectomy with MMC was better in the younger-age group than in the older-age group. Specifically, the younger-age group showed a more prominent and more localized bleb with less vascularity.
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Change history
21 June 2018
Since the online publication of the above article, the authors have noted errors with Table 2. The corrected Table 2 can be found below.
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KHP had full access to the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. The authors alone are responsible for the content and writing of the paper. This research received no specific grant from any funding agency.
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Hoang, T.K.H., Kim, Y.K., Jeoung, J.W. et al. Relationship between age and surgical success after trabeculectomy with adjunctive mitomycin C. Eye 32, 1321–1328 (2018). https://doi.org/10.1038/s41433-018-0071-x
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DOI: https://doi.org/10.1038/s41433-018-0071-x
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