Table 4 Differentiating end-point from gaze-evoked nystagmus

From: Supranuclear eye movements and nystagmus in children: A review of the literature and guide to clinical examination, interpretation of findings and age-appropriate norms

End-point nystagmus

Gaze-evoked nystagmus (GEN)

Unstained (dampens after a few beats)

Sustained. Continues after 20 s of eccentric fixation attempt

Delayed after the eccentric eye movement

Immediate on eccentric fixation

Usually only seen in extreme eccentric gaze

Often seen in only mildly eccentric gaze

Often low amplitude

Often high amplitude

Symmetrical

Often asymmetrical

No rebound nystagmus seen (nystagmus beating in the opposite direction once the eye has returned to its central position after 60 s eccentric gaze)

Rebound often seen

No other supranuclear eye movement abnormalities found.

Very rarely seen without co-existing smooth pursuit abnormalities

Typically horizontal nystagmus on side gazes only

May be horizontal and/or vertical