Abstract
Purpose
To investigate the diagnostic values of intereye or intraeye asymmetry of retinal perfused vessel density and neural structure parameters for detection of glaucoma.
Methods
In total, 152 healthy subjects and 72 bilateral primary open-angle glaucoma (POAG) patients were enrolled. Total POAG group contains all glaucoma patients. Early to moderate POAG group contains patients whose binocular mean defect values were larger than −12 dB. The retinal perfused vessel densities were acquired using optic coherence tomography angiography. The neural structure parameters include RNFL, GCC thickness and its derivative indices like focal loss volume percentage (FLV%) and global loss volume percentage (GLV%). Intereye asymmetry equaled to the absolute difference of parameters between paired eyes. Intraeye asymmetry was defined as absolute difference between the inferior and superior hemisphere values from one random selected eye. The areas under the receiver operating characteristic curves (AUROCs) were calculated to evaluate diagnostic ability.
Results
From pairwise comparison analysis of ROC curves, the intereye asymmetric parameters with the largest diagnostic accuracy were FLV and GLV% (AUROC = 0.944), which were significantly superior to the intereye asymmetry of perfused vessel density in peripapillary area and parafoveal area (P < 0.05). Particularly, the intereye asymmetry of FLV% (AUROC = 0.926) and GLV% (AUROC = 0.950) showed excellent diagnostic precision for detecting early to moderate glaucoma patients. However, the intraeye asymmetry of microvascular parameters and neural structure parameters showed fair diagnostic ability for identifying POAG patients.
Conclusions
The intereye asymmetry of neural structure parameters, particularly the FLV% and GLV%, outperformed the microvascular parameters for identifying POAG patients.
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Acknowledgements
All of authors would like to appreciate Jianfeng Luo, Fudan University, Shanghai, China, for assistance with the statistical analyses in this study.
Funding
This research was supported by the Surface Project of National Natural Science Foundation of China (Grant No. 81770922, China), the project of Shanghai Municipal Commission of Health and Family Planning (Grant No. 201740204, China) the clinical science and technology innovation project of Shanghai Shenkang Hospital Development Center (SHDC12017X18), the western medicine guidance project of Shanghai Committee of Science and Technology (19411961600), the National Key Research & Development Plan (2017YFC0108200) and the Shanghai Committee of Science and Technology (Grant No.13430710500, China).
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Xu, H., Zong, Y., Zhai, R. et al. Intereye and intraeye asymmetry analysis of retinal microvascular and neural structure parameters for diagnosis of primary open-angle glaucoma. Eye 33, 1596–1605 (2019). https://doi.org/10.1038/s41433-019-0451-x
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DOI: https://doi.org/10.1038/s41433-019-0451-x
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