Table 2 Cost considerations.

From: Scope and costs of autorefraction and photoscreening for childhood amblyopia—a systematic narrative review in relation to the EUSCREEN project data

Author [references] (ages tested)

Title

Country and setting

Cost defined

Formal cost-effectiveness analysis/modelling

Options compared

CASP checklist items considered

Comments

Arnold et al. [24] (1–5 years)

The cost and yield of photoscreening: Impact of photoscreening on overall paediatric ophthalmic costs

US (Alaska)

Per screen, per RF, cost of adding to current AAP guidelines eye care

Cost-consequence analysis using reference-case analysis over 10 years of life

Cost of adding photoscreening to current recommendations

8

US setting where the AAP/AAPOS guidelines recomment multiple screenings

Arnold et al. [26] (not stated)

Predictive value of inexpensive digital eye and vision photoscreening: ʻPPV of ABCD’

US (Alaska)

Of different equipment

No

Equipment/interpretation cost of different auto/photo methods

1

 

Arnold and Donahue [94] (6 months–4 years)

The yield and challenges of charitable state-wide photoscreening

US (Alaska and Tennessee)

Per child screened

No

Comparing cost per screened child in two US states

1

 

Cordonnier and Kallay [83] (9–36 months)

Non-cycloplegic screening for refractive errors in children with the hand-held autorefractor Retinomax: final results and comparison with non-cycloplegic photoscreening

Belgium

To diagnosis, including false positives. Per child screened, per child with confirmed risk factors

Estimated cumulative costs to diagnosis

Retinomax vs. photoscreening

5

Enriched population incl higher risk infants, and not community screening.

Donahue et al. [95] (6–47 months)

Lions Clubs International Foundation core four photoscreening: Results from 17 programmes and 400,000 preschool children

US (Multi state) + Taiwan

Per child screened and per child with risk factors detected

No

Programme comparison

3

 

Donahue et al. [36] (6–47 months)

Screening for amblyogenic factors using a volunteer lay network and the MTI photoscreener. Initial results from 15,000 preschool children in a state-wide effort

US (Tennessee)

Per screen

No

No

2

 

Halegoua and Schwartz [93] (6 months–6 years)

Vision photoscreening of infants and young children in a primary care paediatric office: can it identify asymptomatic treatable amblyopic risk factors?

US (New York)

Per device

No

No

2

 

Joish et al. [20] (6 months–8 years)

A cost-benefit analysis of vision screening methods for preschoolers and school-age children

US

Lifetime costs to society

Societal perspective decision-analytic modelling based on published data

VA vs. photoscreening at ages 6–18 months, 3–4 years and 7–8 years

8

Did not consider 5–6 years

Kemper and Clark [118] (3–5 years)

Preschool vision screening in paediatric practices

US

Survey of reimbursement issues as a barrier to screening

No

National reimpursement experiences

n/a

 

Kirk et al. [31] (<2 and 2–4 years)

Preverbal photoscreening for amblyogenic factors and outcomes in amblyopia treatment: early objective screening and visual acuities

USA (Alaska)

Estimated extrapolated cost per US child of adding screening to existing services

Partial

Adding screening at 18 months to existing provision. Comparison with comprehensive eye exam costs

5

 

König and Barry [56] (3 years)

Cost-effectiveness of screening for amblyopia in 3-year-old kindergarten children: Non-cycloplegic refractive screening with the Nikon Retinomax hand-held autorefractor vs. orthoptic visual acuity screening

Germany

Per case detected

Decision-analytic modelling

Five different screening modalities including photoscreening. Modelled cost of adding tests

6

Only considered screening at 3 years of age in German setting (GPs and Paediatricians)

König and Barry [55] (3 years)

Economic evaluation of different methods of screening for amblyopia in kindergarten

See above

See above

See above

See above

8

Conference transaction paper of above study

Lang et al. [32] (3–11 years)

Validated portable paediatric vision screening in the Alaska Bush. A VIPS-like study in the Koyukon

US (Alaska)

Per screen

No

No

1

Small local study

Leman et al. [62] (3–7 years)

A comparison of patched HOTV visual acuity and photoscreening

US (Alaska)

Per test

No

No

3

 

Longmuir et al. [92] (6 months–6 years)

Nine-year results of a volunteer lay network photoscreening programme of 147,809 children using a photoscreener in Iowa

US (Iowa)

Per child screened

No

No

2

 

Lowry et al. [68] (31 months–6 years)

Efficient Referral Thresholds in Autorefraction-Based Preschool Screening

US (California)

Cost per case detected screening and follow-up visits, but not glasses prescriptions

Retrospective evaluation. Modelling to arrive at optimum referral criteria towith minimal cost

Different referral criteria for same photoscreener

6

Optimal model verified with follow-up study. Cost from persective of ʻ3rd party care providers’

Lowry and Campomanes [57] (31 months–6 years)

Cost-effectiveness of School-Based Eye Examinations in Preschoolers Referred for Follow-up From Visual Screening

US (California)

Cost per case detected at follow-up funded a service

Decision-analytic modelling and probabilistic sensitivity analysis

Community vs. mobile follow-up

3

Modelling costs of different types of follow-up, not screening itself

Lowry et al. [80] (3–4 years)

Repeat Retinomax screening changes positive predictive value

US (California)

Cost savings made by re-screening

No

Single screening vs. repeat before referral

4

 

Matsuo et al. [65] (3.5 years)

Is refraction with a hand-held autorefractometer useful in addition to visual acuity testing and questionnaires in preschool vision screening at 3.5 years in Japan?

Japan

No

No

Value of adding photoscreening to established programme

1

Not cost effective

Miller et al. [63] (3–5 years)

Cost-efficient vision screening for astigmatism in native american preschool children

US (Arizona—native American)

Cost of running service/case detected (but not technician time or consumables)

Modelled cost in different size populations to be screened

Four different screening modalities

4

Population with high astigmatism risk. Refrral criterion was ʻenough astigmatism to warrant glasses’

Morgan and Kennemer [96] (5, 7, 11 years)

Off-axis photorefractive eye screening in children

US (East Coast states)

Cost per screen and cost per affected child (incl ref. error)

No

No

2

Early paper

Rein et al. [58] (3 years)

The potential cost-effectiveness of amblyopia screening programmes

USA

Programme cost, referral rate follow-up data

Yes. Randomised person-level simulation. Probablistic sensitivity analysis

Three different screening scenarios including photoscreening at 3 years + VA screening at 5 years

9

All screening modalities likely to be cost effective compared to other public health programmes. The scenario involving photoscreening was most costly. Did not assess photoscreening as a stand-alone test

Terveen et al. [71] (6 months–12 years)

Results of a paediatric vision screening programme in western South Dakota

USA (South Dakota)

Cost for a State run service. Cost of lost earning power of of undetected amblyopia. Cost ratio of cost to QALY

Cost-utility reference-case analysis

SPOT screener compared to no screening

3

 
  1. The CASP checklist score only notes the number of checklist items that were addressed in the paper, not the quality of the evidence.