Fig. 1: Barriers to anti-VEGF delivery to the retina.
From: Use of biomaterials for sustained delivery of anti-VEGF to treat retinal diseases
When delivered topically, anti-VEGF compounds will have to overcome various barriers. This includes physical barriers such as the five layers of the cornea, the blood aqueous barrier and the vitreous before it reaches the retina. Dynamic barriers include the tear film and systemic clearance from conjunctival blood vessels.
