Abstract
Background
To identify predictive factors for exudation for quiescent choroidal neovessels (qCNV) in the fellow eyes of eyes treated for a neovascular age-related macular degeneration (AMD).
Methods
Prospective observational study. One hundred and forty-four contralateral eyes of 144 patients treated for wet AMD were analysed. At a baseline visit, multimodal imaging including dye angiographies and optical coherence tomography angiography (OCT-A) was performed in order to detect qCNV. Patients were followed up for 12 months with a monthly assessment. The manifestation of any type of exudation (either intra- or subretinal fluid or hyperreflective subretinal material) was monitored.
Results
The prevalence of qCNV in the treatment-naive eyes was 15.9% with an incidence over a 12-month period of 2.8%. In total, 40.7% of the overall neovessels remained stable with no sign of exudation, while 59.3% presented some fluid during the follow-up. A statistically significant relationship was established for the following variables preceding the exudation: increase in central macular thickness (OR = 116; 95% CI [4.74; 50530] p = 0.038), increase in pigment epithelial detachment height (OR = 1.76; 95% CI [1.17; 3.18] p = 0.021) and width (OR = 1.53; 95% CI [1.12; 2.62] p = 0.042), increase in neovessels’ surface on OCT-A (OR = 6.32; 95% CI [1.62; 51.0] p = 0.033), emergence of a branching pattern (OR = 7.50; 95% CI[1.37; 61.5] p = 0.032) and appearance of a hypointense halo surrounding the lesion (OR = 10.00; 95% CI [1.41; 206] p = 0.048).
Conclusions
The risk of exudation in the treatment-naive fellow eyes of eyes treated for neovascular AMD was notably increased in the presence of qCNV. The biomarkers identified will help to detect their activation in order to ensure prompt antiangiogenic therapy.
Similar content being viewed by others
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
Augood CA, Vingerling JR, de Jong PTVM, Chakravarthy U, Seland J, Soubrane G, et al. Prevalence of age-related maculopathy in older Europeans: the European Eye Study (EUREYE). Arch Ophthalmol. 2006;124:529–35.
Friedman DS, O’Colmain BJ, Muñoz B, Tomany SC, McCarty C, de Jong PTVM, et al. Prevalence of age- related macular degeneration in the United States. Arch Ophthalmol. 2004;122:564–72.
Wong WL, Su X, Li X, Cheung CMG, Klein R, Cheng C-Y, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health. 2014;2:e106–e116.
Ferris FL, Fine SL, Hyman L. Age-related macular degeneration and blindness due to neovascular maculopathy. Arch Ophthalmol. 1984;102:1640–2.
Chopra R, Wagner SK, Fasler K, Kortuem KU, Pontikos N, Afshar F, et al. Development of neovascular age-related macular degeneration in fellow eyes of patients undergoing intravitreal anti-VEGF therapy at a large tertiary ophthalmic hospital. Investig Ophthalmol Vis Sci. 2018;59:816–816.
Jia Y, Bailey ST, Wilson DJ, Tan O, Klein ML, Flaxel CJ, et al. Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration. Ophthalmology. 2014;121:1435–44.
Coscas GJ, Lupidi M, Coscas F, Cagini C, Souied EH. Optical coherence tomography angiography versus traditional multimodal imaging in assessing the activity of exudative age-related macular degeneration: a new diagnostic challenge. Retina. 2015;35:2219–28.
Spaide RF, Fujimoto JG, Waheed NK, Sadda SR, Staurenghi G. Optical coherence tomography angiography. Prog Retin Eye Res. 2018;64:1–55.
Roisman L, Goldhardt R. OCT angiography: an upcoming non-invasive tool for diagnosis of age-related macular degeneration. Curr Ophthalmol Rep. 2017;5:136–40.
Nagiel A, Sadda SR, Sarraf D. A promising future for optical coherence tomography angiography. JAMA Ophthalmol. 2015;133:629–30.
de Carlo TE, Romano A, Waheed NK, Duker JS. A review of optical coherence tomography angiography (OCTA). Int J Retin Vitreous. 2015;1:5.
Faridi A, Jia Y, Gao SS, Huang D, Bhavsar KV, Wilson DJ, et al. Sensitivity and specificity of OCT angiography to detect choroidal neovascularization. Ophthalmol Retin. 2017;1:294–303.
Querques G, Srour M, Massamba N, Georges A, Ben Moussa N, Rafaeli O, et al. Functional characterization and multimodal imaging of treatment-naive ‘quiescent’ choroidal neovascularization. Investig Ophthalmol Vis Sci. 2013;54:6886–92.
Carnevali A, Cicinelli MV, Capuano V, Corvi F, Mazzaferro A, Querques L, et al. Optical coherence tomography angiography: a useful tool for diagnosis of treatment-naïve quiescent choroidal neovascularization. Am J Ophthalmol. 2016;169:189–98.
de Oliveira Dias JR, Zhang Q, Garcia JMB, Zheng F, Motulsky EH, Roisman L, et al. Natural history of subclinical neovascularization in nonexudative age-related macular degeneration using swept-source OCT angiography. Ophthalmology. 2018;125:255–66.
Carnevali A, Sacconi R, Querques L, Marchese A, Capuano V, Rabiolo A, et al. Natural history of treatment-naïve quiescent choroidal neovascularization in age-related macular degeneration using oct angiography. Ophthalmol Retin. 2018;2:922–30.
Kuehlewein L, Bansal M, Lenis TL, Iafe NA, Sadda SR, Bonini Filho MA, et al. Optical coherence tomography angiography of type 1 neovascularization in age-related macular degeneration. Am J Ophthalmol. 2015;160:739–48.e2.
El Ameen A, Cohen SY, Semoun O, Miere A, Srour M, Quaranta-El Maftouhi M, et al. TYPE 2 neovascularization secondary to age-related macular degeneration imaged by optical coherence tomography angiography. Retina. 2015;35:2212–8.
Miere A, Querques G, Semoun O, El Ameen A, Capuano V, Souied EH. Optical coherence tomography angiography in early type 3 neovascularization. Retina. 2015;35:2236–41.
Al-Sheikh M, Iafe NA, Phasukkijwatana N, Sadda SR, Sarraf D. Biomarkers of neovascular activity in age-related macular degeneration using optical coherence tomography angiography.Retina. 2018;38:220–30.
Roisman L, Zhang Q, Wang RK, Gregori G, Zhang A, Chen C-L, et al. Optical coherence tomography angiography of asymptomatic neovascularization in intermediate age-related macular degeneration. Ophthalmology. 2016;123:1309–19.
Palejwala NV, Jia Y, Gao SS, Liu L, Flaxel CJ, Hwang TS, et al. Detection of non-exudative choroidal neovascularization in age-related macular degeneration with optical coherence tomography angiography. Retina. 2015;35:2204–11.
Capuano V, Miere A, Querques L, Sacconi R, Carnevali A, Amoroso F, et al. Treatment-naïve quiescent choroidal neovascularization in geographic atrophy secondary to nonexudative age-related macular degeneration. Am J Ophthalmol. 2017;182:45–55.
Nehemy MB, Brocchi DN, Veloso CE. Optical coherence tomography angiography imaging of quiescent choroidal neovascularization in age-related macular degeneration. Ophthalmic Surg Lasers Imaging Retin. 2015;46:1056–7.
Schneider U, Gelisken F, Inhoffen W, Kreissig I. Indocyanine green angiographic findings in fellow eyes of patients with unilateral occult neovascular age-related macular degeneration. Int Ophthalmol. 1997;21:79–85.
Rispoli M, Savastano MC, Lumbroso B. Quantitative vascular density changes in choriocapillaris around CNV after Anti-VEGF treatment: dark halo. Ophthalmic Surg Lasers Imaging Retin. 2018;49:918–24.
Xu D, Dávila JP, Rahimi M, Rebhun CB, Alibhai AY, Waheed NK, et al. Long-term progression of type 1 neovascularization in age-related macular degeneration using optical coherence tomography angiography. Am J Ophthalmol. 2018;187:10–20.
Acknowledgements
This work was funded by the Francomtoise Association for Research in Ophthalmology (AFCRO, Besançon, France). The authors declare their independence in reporting the data.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
LS, PL, ASG, MS, and MP: None. BD: Consultant (Alcon, Théa, Allergan), MS: Consultant (Novartis, Bayer, Allergan).
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Solecki, L., Loganadane, P., Gauthier, AS. et al. Predictive factors for exudation of quiescent choroidal neovessels detected by OCT angiography in the fellow eyes of eyes treated for a neovascular age-related macular degeneration. Eye 35, 644–650 (2021). https://doi.org/10.1038/s41433-020-0936-7
Received:
Revised:
Accepted:
Published:
Version of record:
Issue date:
DOI: https://doi.org/10.1038/s41433-020-0936-7
This article is cited by
-
Short-term natural history of macular neovascularization in nonexudative age-related macular degeneration using multimodal imaging
Scientific Reports (2025)
-
Prediction of activity in eyes with macular neovascularization due to age-related macular degeneration using deep learning
Eye (2024)
-
Optical Coherence Tomography Angiography: A 2023 Focused Update on Age-Related Macular Degeneration
Ophthalmology and Therapy (2024)
-
Comparison between indocyanine green angiography and optical coherence tomography angiography for the detection of nonexudative macular neovascularization
Graefe's Archive for Clinical and Experimental Ophthalmology (2024)
-
Predict and Protect: Evaluating the Double-Layer Sign in Age-Related Macular Degeneration
Ophthalmology and Therapy (2024)
