Abstract
Objectives
To investigate the results of partial lamellar sclerouvectomy (PLSU) for anteriorly located uveal tumours.
Methods
We reviewed the tumour features, histopathologic findings, complications, visual acuity outcomes, eye preservation, metastasis, and mortality data of 56 cases with uveal tumours who underwent PLSU between February 1999 and February 2019.
Results
The mean largest tumour base diameters were 5.8 × 3.4 mm and the mean tumour thickness was 3.3 mm. Histopathologically, 30 (53.6%) eyes had malignant melanoma, 13 (23.2%) had nevus, 5 (8.9%) had iris stromal cyst, 4 (7.1%) had melanocytoma, 2 (3.6%) had Fuchs’ adenoma, 1 (1.8%) had iris pigment epithelial cyst, and 1 (1.8%) had invasive breast cancer metastasis. The most common postoperative complications included cataract in 21 (37.5%) eyes, vitreous haemorrhage in 15 (26.8%), scleral thinning in 10 (17.9%), and hyphema in 6 (10.7%). At a mean follow-up of 40.4 (range: 10–201) months, tumour recurrence was observed in 2/30 (6.7%) eyes with melanoma and 1/5 (20.0%) eye with iris stromal cyst. Eyes with recurrent melanoma were treated with enucleation. Liver metastasis developed in only 1 (3.3%) melanoma case. All patients were alive at the end of follow-up.
Conclusions
PLSU is a successful treatment method for many anteriorly located uveal tumours. In our series, the overall tumour recurrence and globe salvage rates were 5.4% and 96.4% respectively. Among melanoma cases, the metastasis rate was 3.3% and survival rate was 100%.
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Acknowledgements
The authors acknowledge Hatice Kaykusuz, MD from the Anaesthesiology Department, Ankara University Faculty of Medicine and Funda Seher Özalp Ateş, Msc from the Biostatistics Department, Ankara University Faculty of Medicine for their contributions in the preparation of the paper. There are no sources of support including sponsorship (e.g. university, charity, commercial organisation) and sources of material (e.g. novel drugs) not available commercially.
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Mirzayev, I., Gündüz, A.K. & Okçu Heper, A. Partial lamellar sclerouvectomy surgery for anteriorly located uveal tumour resection: a 20-year experience. Eye 36, 969–977 (2022). https://doi.org/10.1038/s41433-021-01545-7
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DOI: https://doi.org/10.1038/s41433-021-01545-7
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