Fig. 2: Structural view of PAX6 and HSF4 proteins.
From: Variants in PAX6, PITX3 and HSF4 causing autosomal dominant congenital cataracts
A Crystal structure of the human PAX-6 paired domain-dna complex reveals a general model for PAX protein-dna interactions- X-ray diffraction, 2.50 A monomer (4-133 aminoacids). Wt -V62 PAX6: https://swissmodel.expasy.org/repository/uniprot/P26367 Mut - M62-PAX6: https://swissmodel.expasy.org/interactive/1hpd5p/models/. B Structure of the DNA-binding domain of HSF2 with sequence homology to HSF4 at aminoacids position (pro18-Val121). Wt: L114 https://swissmodel.expasy.org/interactive/0QmfH7/models/ Heat shock factor protein 2-Human HSF2 DNA Binding Domain in complex with 3-site HSE DNA at 2.1 Angstroms Resolution; Mut: P114 https://swissmodel.expasy.org/interactive/Fx4QGZ/models/.
