Abstract
Purpose
To compare the effectiveness of three procedures: modified Nishida procedure alone vs modified Nishida procedure combined with medial rectus recession (MRc) vs modified Nishida procedure combined with MRc and botulinum toxin (BT) for severe unilateral sixth nerve palsy.
Design
Consecutive, interventional case series.
Methods
The medical records of a consecutive series of patients with severe unilateral sixth nerve palsy who underwent modified Nishida procedure in multiple centres were reviewed. Surgical technique was decided preoperatively at the surgeon’s discretion. The preoperative and postoperative findings were compared.
Results
Of the 43 patients with abducens palsy that received the procedure, 32 were included (mean age 38.6 ± 19.8 years). Mean preoperative deviation was 63.0 ± 27.3 prism dioptres (PD) and mean limitation of abduction −4.5 ± 1.2. Five patients underwent a modified Nishida procedure alone, 24 patients had an additional MRc and 3 patients were also injected with BT. Overall, the average correction of modified Nishida technique by itself was 29.4 ± 6.6 PD (range 20–36) and adding a MRc corrected 62.6 ± 23.8 PD (range 24–120). Modified Nishida procedure, MRc and BT altogether corrected 95.0 ± 18.0 PD (range 75–110). No postoperative complications were observed in any of the patients.
Conclusions
Excellent outcomes with fewer complications are obtained with modified Nishida procedure alone. The need for additional procedures such as MRc and BT which increase the effect in primary position can be determined depending on passive duction and preoperative horizontal deviation.
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References
Yurdakul NS, Ugurlu S, Maden A. Surgical management of chronic complete sixth nerve palsy. Ophthalmic Surg Lasers Imaging. 2011;42:72–7.
Holmes JM, Leske DA, Christiansen SP. Initial treatment outcomes in chronic sixth nerve palsy. J AAPOS Publ Am Assoc Pediatr Ophthalmol Strabismus. 2001;5:370–6.
Bansal S, Khan J, Marsh IB. Unaugmented vertical muscle transposition surgery for chronic sixth nerve paralysis. Strabismus.2006;14:177–81.
Holmes JM, Leske DA. Long-term outcomes after surgical management of chronic sixth nerve palsy. J AAPOS Publ Am Assoc Pediatr Ophthalmol Strabismus. 2002;6:283–8.
Simons BD, Siatkowski RM, Neff AG. Posterior fixation suture augmentation of full-tendon vertical rectus muscle transposition for abducens palsy. J Neuroophthalmol. 2000;20:119–22.
Foster RS. Vertical muscle transposition augmented with lateral fixation. J AAPOS Publ Am Assoc Pediatr Ophthalmol Strabismus. 1997;1:20–30.
Britt MT, Velez FG, Thacker N, Alcorn D, Foster RS, Rosenbaum AL. Partial rectus muscle-augmented transpositions in abduction deficiency. J AAPOS Publ Am Assoc Pediatr Ophthalmol Strabismus. 2003;7:325–32.
Gunton KB. Vertical rectus transpositions in sixth nerve palsies. Curr Opin Ophthalmol. 2015;26:366–70.
Hummelsheim E. Weitere Erfahrungen mit partieller Sehnenuberpflanzung an den Augenmuskeln. Arch Augenheilkd. 1908;62:71.
O’Connor R. Transplantation of ocular muscles. Am J Ophthalmol. 1921;4:838.
Jensen CD. Rectus muscle union: a new operation for paralysis of the rectus muscles. Trans Pac Coast Otoophthalmol Soc Annu Meet. 1964;45:359–87.
Hummelshein E. Über Schnentransplantation am Auge. Ophthal Gesselschaft. 1907;34:248.
SCHILLINGER RJ. A new type of tendon transplant operation for abducens paralysis. J Int Coll Surg. 1959;31:593–600.
Brooks SE, Olitsky SE, deB Ribeiro G. Augmented Hummelsheim procedure for paralytic strabismus. J Pediatr Ophthalmol Strabismus. 2000;37:189–95; quiz 226–7.
Flanders M, Qahtani F, Gans M, Beneish R. Vertical rectus muscle transposition and botulinum toxin for complete sixth nerve palsy. Can J Ophthalmol. 2001;36:18–25.
Simon JW, Grajny A. Anterior segment ischemia following augmented 2-muscle transposition surgery. J AAPOS Publ Am Assoc Pediatr Ophthalmol Strabismus. 2004;8:586–7.
von Noorden GK. Anterior segment ischemia following the Jensen procedure. Arch Ophthalmol (Chic, Ill 1960). 1976;94:845–7.
Mehendale RA, Dagi LR, Wu C, Ledoux D, Johnston S, Hunter DG. Superior rectus transposition and medial rectus recession for Duane syndrome and sixth nerve palsy. Arch Ophthalmol (Chic, Ill 1960). 2012;130:195–201.
Velez FG, Oltra E, Isenberg SJ, Pineles SL. Assessment of torsion after superior rectus transposition with or without medial rectus recession for Duane syndrome and abducens nerve palsy. J AAPOS Publ Am Assoc Pediatr Ophthalmol Strabismus. 2014;18:457–60.
Patil-Chhablani P, Kothamasu K, Kekunnaya R, Sachdeva V, Warkad V. Augmented superior rectus transposition with medial rectus recession in patients with abducens nerve palsy. J AAPOS Publ Am Assoc Pediatr Ophthalmol Strabismus. 2016;20:496–500.
Agarwal R, Sharma M, Saxena R, Sharma P. Surgical outcome of superior rectus transposition in esotropic Duane syndrome and abducens nerve palsy. J AAPOS Publ Am Assoc Pediatr Ophthalmol Strabismus. 2018;22:12–16.e1.
Velez FG, Chang MY, Pineles SL. Inferior rectus transposition: a novel procedure for abducens palsy. Am J Ophthalmol. 2017;177:126–30.
Lee Y-H, Lambert SR. Outcomes after superior rectus transposition and medial rectus recession versus vertical recti transposition for sixth nerve palsy. Am J Ophthalmol. 2017;177:100–5.
Nishida Y, Inatomi A, Aoki Y, Hayashi O, Iwami T, Oda S, et al. A muscle transposition procedure for abducens palsy, in which the halves of the vertical rectus muscle bellies are sutured onto the sclera. Jpn J Ophthalmol. 2003;47:281–6.
Muraki S, Nishida Y, Ohji M. Surgical results of a muscle transposition procedure for abducens palsy without tenotomy and muscle splitting. Am J Ophthalmol 2013;156:819–24.
Clark RA, Demer JL. Rectus extraocular muscle pulley displacement after surgical transposition and posterior fixation for treatment of paralytic strabismus. Am J Ophthalmol. 2002;133:119–28.
Hussein MAW, Coats DK. Limitation of opposing ductions following augmented horizontal rectus muscle transposition. Am J Ophthalmol. 2003;136:947–9.
González M, del P, Kraft SP. Outcomes of three different vertical rectus muscle transposition procedures for complete abducens nerve palsy. J AAPOS Publ Am Assoc Pediatr Ophthalmol Strabismus. 2015;19:150–6.
Nishida Y, Hayashi O, Oda S, Kakinoki M, Miyake T, Inoki Y, et al. A simple muscle transposition procedure for abducens palsy without tenotomy or splitting muscles. Jpn J Ophthalmol. 2005;49:179–80.
Sabermoghadam A, Etezad Razavi M, Sharifi M, Kiarudi MY, Ghafarian S. A modified vertical muscle transposition for the treatment of large-angle esotropia due to sixth nerve palsy. Strabismus.2018;26:145–9.
Marcon GB, Pittino R, Paris V, Göky B, De Liaño RG. Muscle union technique for correction of complex paralytic strabismus: a multicenter, multicountry study. Trans 36° Meet. Eur. Strabismological Assoc. Marseille: 3–7.
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EHG, BBB and RGDL contributed to the conception, design, acquisition, analysis and interpretation of the work. SBO, PS, AAR, DPD, YHL, DCC and AM contributed to the acquisition of the data. EHG, BBB and RGDL drafted the work. All authors revised the manuscript and approved the final version to be published.
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Hernandez-García, E., Burgos-Blasco, B., Özkan, S.B. et al. A comparative multicentric long-term study of un-augmented modified Nishida procedure vs augmentation in unilateral sixth nerve palsy. Eye 37, 170–175 (2023). https://doi.org/10.1038/s41433-021-01917-z
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DOI: https://doi.org/10.1038/s41433-021-01917-z


