Table 2 Study characteristics.

Brandberg et al. [42]

51.51% female

female x̅ age = 63 (27–88)

male x̅ age = 64 (31–87)

SD (±) = NR

T1 = 99

T2 = 85

T3 = 78

Enucleation, 49 (49)

Ruthenium plaque radiotherapy, 50(51)

Origin/location: Ciliary body (n = 6)

Size: 4–22 mm diameter and 2–20 mm thickness.

TNM: NR

NR

0 (First admission)

T2 = 2

T3 = 12

Sweden

Brown et al. [32]

49% female

age = NR

T1 = 411

T2 = 325

T3 = 261

Enucleation 66 (25.3)

Brachytherapy: ruthenium plaque 116 (44.4)

Proton beam radiotherapy 49 (18.8)

Local resection 9 (3.4)

Endoresection 12 (4.6)

Photo dynamic therapy 7 (2.7)

Transpupillary thermal therapy 2 (0.8)

Origin/location: choroid and ciliary body

Size: NR

TNM: NR

36.5%

6

T2 = 12

T3 = 24

UK

Brown et al. [35]

48.4% female

x age = 69.03 (±12.12)

T1 = 814

T2 = 773

T3 = 706

T4 = 619

T5 = 557

T6 = 453

Plaque radiotherapy 327 (46.2)

Proton beam radiotherapy 167 (23.6)

Enucleation 155 (21.9)

Resection 34 (4.8)

Other 25 (3.5)

Origin/location: choroid and ciliary body

Size: NR

TNM: NR

NR

6

T2 = 12

T3 = 24

T4 = 36

T5 = 48

T6 = 60

UK

Brown et al. [36]

47.0% female

x age = 69.48 (±11.57)

T1 = 814

T2 = 773

T3 = 706

T4 = 619

T5 = 557

T6 = 453

Plaque radiotherapy 219 (48.3)

Proton beam radiotherapy 99 (21.9)

Enucleation 92 (20.3)

Resection 26 (5.7)

Other 17 (3.8)

Origin/location: choroid and ciliary body

Size: NR

TNM: NR

44.3%

6

T2 = 12

T3 = 24

T4 = 36

T5 = 48

T6 = 60

UK

Damato et al. [38]

48.30% female

female x̅ = 62.5 (21.6–94.4)

male x̅ = 62 (25.9–91.7)

SD (±) = NR

N = 1596

Ruthieum plaque therapy or proton beam therapy, 1154 (72.3)

Enucleation, 442 (27.7)

Origin/location: choroid & ciliary body

Size: NR

TNM: NR

NR

6

T2 = 12

T3 = 24

(Up to 10 years)

UK

Damato et al. [37]

48.30% female

age = NR

N = 1569

Ruthieum plaque therapy or proton beam therapy, 1154 (72.3)

Enucleation, 442 (27.7)

Origin/location: choroid and ciliary body

Size: NR

TNM: NR

NR

6

T2 = 12

T3 = 24

(Up to 10 years)

UK

Hope-Stone et al. [33]

51.30% female

age = NR

T1 = 194

T2 = 155

T3 = 132

Enucleation 66, (57.4)

Proton beam therapy 49 (42.6)

Origin/location: choroid and ciliary body

Size: Height 5.59 mm (SD = 3.74) 0.6–14.8

Diameter 13.04 mm (SD = 4.56), 0.99–20.5

TNM: NR

40.7%

6

T2 = 12

T3 = 24

UK

Hope-Stone et al. [34]

47% female

x̅ age = 64 (23–94)

SD (±) = NR

T = 411

T = 325

T = 291

Ruthenium plaque radiotherapy 174, (28.5)

Proton beam radiotherapy 72 (17.5)

Trans-scleral local resection 15 (3.6)

Endoresection 21 (5.1)

Enucleation 117 (28.5)

Photo dynamic therapy 10, (2.4), Transpupillary thermal therapy 2, (0.5).

Origin/location: choroid (381) and ciliary body (30)

Size: NR

TNM: NR

NR

6

T2 = 12

T3 = 24

UK

Klingenstein [41]

47.25% female

x̅ age = 63 (27–86)

SD (±) = NR

N = 91

Cyberknife radiosurgery

Origin/location: Uveal Melanoma with

- ciliary body (5)

- peripapillary region (15)

- posterior pole (14)

- midperiphery (34)

- periphery (23)

Size: NR

TNM:

T1 = 12

T2 = 29

T3 = 45

NR

0 (First admission)

T2 = 3

T3 = 15

Germany

Lieb et al. [43]

33.3% female

Genetic Test group: 57.68 (±12.03)

51.8% female

Observational: 63.08 (±11.4)

T1 = 186

T2 = 163

T3 = 154

T4 = 150

T5 = 142

Enucleation (test: 23, observational: 8), Brachytherapy (test: 25, observational: 90),

Endo-resection with adjuvant brachytherapy (test: 7, observational: 3), proton therapy (test: 6, observational: 7).

Origin/location: diagnosis of UM with possibility of tumour sample removal.

Size: NR

TNM: NR

NR

0

(First admission)

T2 = 6–12 wks

T3 = 6

T4 = 12

T5=

Germany

Melia et al. [45]

47.36% female

x̅ age = 62 (29–87)

SD (±) = NR

T1 = 206

T2 = NR

T3 = NR

T4 = 178

T5 = 168

T6 = 60

Iodine 125 brachytherapy 103 (50)

Enucleation 103 (50)

Origin/location: unilateral choroidal

Size: 2.5–10.0 mm in apical height and no more than 16.0 mm in basal diameter.

TNM: NR

9%

6 weeks

T2 = 12

T3 = 24

T4 = 36

T5 = 48

T6 = 60

USA

Schuermeyer et al. [40]

44% female

x̅ age = 60.7

SD = (±14.8)

T1 = 96

T2 = 68 (HADS)/65 (DRS)

T3 = 79 (HADS)/77 (DRS)

-

Origin/location: NR

Size: NR

TNM: NR

NR

0 (Immediately pre treatment)

T2 = 3

T3 = 12

USA

Van Beek et al. [44]

46.90% female

x̅ age = 65 (33–89)

SD (±) = NR

T1 = 111

T2 = 113

T3 = 110

T4 = 104

T5 = 75

T6 = 61

T7 = 53

Fractionated stereotactic radiotherapy 66, (58)

Enucleation 47 (42)

Origin/location: N/A

Size (mm): fRST: mean largest tumour diameter 67.0 (12.1 SD)

mean tumour thickness 6.0 (2.5)

enucleation: mean largest tumour diameter 63.3 (12.6)

mean tumour thickness 7.5 (4.3)

TNM: T1 = 29

T2 = 35

T3 = 40

T4 = 9

NR

0 (Second admission)

T2 = 2

T3 = 6

T4 = 12

T5 = 24

T6 = 36

T7 = 48

Netherlands