Fig. 1: Transvitreal incisional biopsy from a choroidal metastasis of breast cancer. | Eye

Fig. 1: Transvitreal incisional biopsy from a choroidal metastasis of breast cancer.

From: Overrepresentation of human epidermal growth factor receptor 2 positive- and Luminal B breast cancer metastases in the eyes and orbit

Fig. 1

A Irregular clusters of enlarged epithelioid cells grow in choroidal tissue with severe fibrotic changes, which may be a reaction to tumour infiltration and inflammation. B In larger magnification, the infiltrating tumour cells are seen with pleomorphism, hyperchromasia, and a tendency to form rounded gland-like structures. Most of the tumour cell nuclei were positive for ER (red, chromogen), but negative for PR (blue, haematoxylin). There was complete and intense membranous HER2 positivity in all tumour cells. The proliferation marker Ki67 was positive in a majority of tumour cell nuclei, in this area about 140 of 180 tumour cells (78%), which suggests a very high rate of proliferation. Any visible staining above background sufficed for positive classification of a tumour cell in stains with ER, PR and Ki67. ER oestrogen receptor. PR progesterone receptor. HER2 human epidermal growth factor receptor 2. Scale bars: A 200 µm. B 100 µm. ER, PR, HER2 and Ki67 40 µm.

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