The Endophthalmitis Vitrectomy Study sought to evaluate the roles of immediate vitrectomy and systemic antibiotic treatment in the management of post-operative endophthalmitis following cataract surgery or secondary intraocular lens implantation, presenting within 6 weeks of the original surgery (median time to presentation was 6 days). The intervention (either vitrectomy, or vitreous tap) was performed within 6 h of the initial examination. All patients received intravitreal amikacin (0.4 mg) and vancomycin (0.1 mg), in addition to sub-conjunctival and topical antibiotics and steroids, with oral prednisolone (30 mg twice daily for 5–10 days). BCVA – best corrected visual acuity; IOL – intraocular lens; IV – intravenous; ETDRS – Early Treatment Diabetic Retinopathy Study; LP – light perception vision; VA – visual acuity; ns – not statistically significant.

Reference: Endophthalmitis Vitrectomy Study Group. A Randomized Trial of Immediate Vitrectomy and of Intravenous Antibiotics for the Treatment of Postoperative Bacterial Endophthalmitis. Arch Ophthalmol. 1995;113:1479-1496.

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