Table 2 Proportion (%) of treatment-naïve and non-treatment-naïve patients experiencing greater than 5, 10 or 15 best corrected visual acuity (BCVA) letter gains or losses at Month 12 (M12) and Month 24 (M24).
Treatment-naïve | Non-treatment-naïve | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Letter Change | Proportion of patients n (%) | Number of injections Mean (SD) | r | p-value | Proportion of patients n (%) | Number of injections Mean (SD) | r | p-value | ||
M12 | All Patients | 388 (100) | - | - | - | 169 (100) | - | - | - | |
Patients Receiving IVT-AFL | 388 (100) | 6.4 (2.1) | - | - | 169 (100) | 6.0 (2.4) | - | - | ||
Gain | ≥ 5 | 156 (40.2) | 6.4 (1.9) | 0.19 | 0.02 | 51 (30.2) | 6.6 (2.4) | 0.00 | 0.97 | |
≥ 10 | 78 (20.1) | 6.5 (2.1) | 0.28 | 0.01 | 25 (14.8) | 6.8 (2.6) | −0.02 | 0.93 | ||
≥ 15 | 34 (8.8) | 6.8 (2.2) | 0.44 | 0.01 | 8 (4.7) | 6.9 (2.2) | −0.05 | 0.91 | ||
Loss | ≥ 5 | 64 (16.5) | 6.4 (2.1) | 0.01 | 0.94 | 42 (24.9) | 5.6 (2.4) | −0.07 | 0.65 | |
≥ 10 | 38 (9.8) | 6.5 (2.0) | 0.05 | 0.77 | 24 (14.2) | 5.7 (2.1) | −0.15 | 0.49 | ||
≥ 15 | 23 (5.9) | 6.7 (2.2) | 0.20 | 0.36 | 9 (5.3) | 6.1 (2.6) | −0.15 | 0.71 | ||
M24 | All Patients | 326 (100) | - | - | - | 135 (100) | - | - | - | |
Patients Receiving IVT-AFL | 241 (73.9) | 3.7 (2.3) | - | - | 106 (78.5) | 4.3 (2.5) | - | - | ||
Gain | ≥ 5 | 124 (38.0) | 3.6 (2.1) | 0.08 | 0.42 | 43 (31.9) | 4.5 (2.5) | −0.04 | 0.83 | |
≥ 10 | 54 (16.6) | 3.7 (2.3) | 0.18 | 0.26 | 20 (14.8) | 4.7 (2.0) | −0.18 | 0.47 | ||
≥ 15 | 27 (8.3) | 4.1 (2.4) | 0.02 | 0.92 | 9 (6.7) | 4.4 (2.0) | −0.30 | 0.51 | ||
Loss | ≥ 5 | 85 (26.1) | 3.7 (2.3) | 0.03 | 0.81 | 39 (28.9) | 4.7 (2.6) | 0.14 | 0.47 | |
≥ 10 | 50 (15.3) | 3.6 (2.2) | 0.01 | 0.96 | 25 (18.5) | 4.2 (2.1) | 0.09 | 0.73 | ||
≥ 15 | 24 (7.4) | 3.3 (1.8) | −0.18 | 0.45 | 17 (12.6) | 4.2 (2.2) | 0.09 | 0.78 | ||
