Abstract
The study aimed to compare and rank the accuracy of formulas for calculating intraocular lens (IOL) power in paediatric eyes in a systematic way. A literature search was conducted in Pubmed, Web of Science, Cochrane Library, and EMBASE by December 2021. Combined with traditional and network meta-analysis, we analysed the percentages of paediatric eyes with prediction error (PE) within ±0.50 dioptres (D) and ±1.00 D as the outcome measurements among different formulas. Subgroup analyses stratified by age were also undertaken. Thirteen studies with 1781 eyes comparing 8 calculation formulas were included. For the traditional meta-analysis results, Sanders-Retzlaff-Kraff theoretical (SRK/T) (risk ratios (RR), 1.15; 95% confidence intervals (CI), 1.03–1.30) performed significantly better than the SRKII formula for the percentage of eyes with PE within ±0.50 D. In addition, SRK/T (RR, 1.10; 95% CI, 1.02–1.18) and Holladay 1(RR, 1.15; 95% CI, 1.01–1.30) both performed significantly better than the SRKII formula for the percentage of eyes with PE within ±1.00 D. Considering the ranking based on the surface under the cumulative ranking curve (SUCRA) by Bayesian method, the top four formulas were Barrett Universal II (UII), Haigis, Holladay 1, and SRK/T on the percentage of PE within ±0.50 D, whereas the top four formulas were Barrett UII, Holladay 1, SRK/T, and Hoffer Q formulas on the percentage of PE within ±1.00D. Concerning both outcome measurements of rank probabilities, the top three Barrett UII, SRK/T, and Holladay 1 formulas were considered to provide more accuracy for IOL power calculation in paediatric cataract eyes, and Barrett UII tends to perform better in older children.
摘要
本研究旨在以应用系统分析比较并排序关于计算儿童白内障眼人工晶状体 (IOL) 植入度数公式的准确性。截至2021年12月, 在Pubmed、Web of Science、Cochrane Library和EMBASE中进行了文献检索。结合传统和网状荟萃分析, 我们分析了不同公式之间的测量结果, 即IOL预测误差 (PE) 分别在±0.50屈光度 (D) 和±1.00 D以内的儿童眼的百分比。同时进行按年龄分层的亚组分析。共纳入了13项研究, 涉及1781只眼, 比较了8种IOL计算公式。对于传统的荟萃分析结果, PE在±0.50 D以内的百分比的结果中, Sanders-Retzlaff-Kraff (SRK/T)理论公式(风险比(RR), 1.15; 95%置信区间(CI), 1.03–1.30)表现明显优于SRKII公式。此外, SRK/T (RR, 1.10; 95% CI, 1.02–1.18)和Holladay 1(RR, 1.15; 95% CI, 1.01–1.30)的PE在±1.00 D以内的百分比均显著优于SRKII。考虑到贝叶斯方法中基于累积排名曲线下面积(SUCRA)的排名可能性结果, PE在±0.50 D以内的百分比中排前四名公式是Barrett Universal II(UII), Haigis、Holladay 1、和SRK/T。对于PE在±1.00 D以内的百分比中, 排名前四的公式是Barrett UII、Holladay 1、SRK/T和Hoffer Q。根据两种测量结果排名的可能性, Barrett UII、SRK/T和Holladay 1公式作为前三名被认为可以为小儿白内障眼的IOL度数计算提供更高的准确性, 并且Barrett UII在年龄较大的儿童中表现更好。
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This work was supported by the National Natural Science Foundation of China (Grant No. 81770907 and No. 82070942).
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YYH was responsible for registering the protocol, conducting literature search, screening potentially eligible studies, extracting and analysing data, interpreting results, writing and revising the paper. YS was contributed to screen potentially eligible studies, extract and analyse data, and revise the paper. BHX and MA responsible for conducting literature search, screening potentially eligible studies, and revising the paper. YHJ contributed to design the work, screen potentially eligible studies, provide instructions on the work, supervise the entire process, and revise the paper.
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Hong, Y., Sun, Y., Xiao, B. et al. A Bayesian network meta-analysis on comparisons of intraocular lens power calculation methods for paediatric cataract eyes. Eye 37, 3313–3321 (2023). https://doi.org/10.1038/s41433-023-02510-2
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DOI: https://doi.org/10.1038/s41433-023-02510-2
