Fig. 4: Accurate estimation of severity by the 10-2 alone but over-estimation when combined with OCT.

An example case of when the gradings based on the 10-2 accurately estimated severity, however the combination of 10-2 with OCT over-estimated the severity. In this eye, according to the RS (black rectangle) there was superior hemifield involvement on the RNFL probability map (v) based on 6 aS-aF locations (blue arrows) and no locations that met the threshold criteria for central 5-degree involvement (white circle) on the GCL probability map (iv). Therefore, the RS severity was classified as moderate. Based on the combination of the 10-2 with the OCT (iii and ii respectively, red rectangles) the graders classified severity as advanced, due to the superior RNFL arcuate (black arrows) extending to the central 5-degree as seen on the GCL probability map (red arrows). However, based only on the 10-2 visual field the graders classified the severity of this eye as moderate due to superior hemifield involvement (black arrow), in agreement with the RNFL defect and the RS decision.