Table 1 Studies using OCT-A to investigate the retinal vasculature in age-related macular degeneration (AMD).
From: The role of the retinal vasculature in age-related macular degeneration: a spotlight on OCTA
Study | Year | Stages of AMD investigated | Number of AMD eyes | Comparators | Comparator eyes | Vascular anatomy investigated | OCT-A and OCT indices used | OCT-A device used |
|---|---|---|---|---|---|---|---|---|
Toto | 2016 | Early, Intermediate | 14, 23 | Healthy Controls | 21 | Superficial Retinal Plexus, Deep Retinal Plexus | Vessel Density, Choroidal Thickness | XR Avanti AngioVue OCTA (Optovue Inc, Fremont, CA, USA) |
Toto | 2017 | Intermediate (±pre-atrophic changes) | 15, 15 | Healthy Controls | 15 | Superficial Retinal Plexus, Deep Retinal Plexus | Flow Density, Macular Thickness | XR Avanti AngioVue OCTA (Optovue Inc, Fremont, CA, USA) |
Lee, B | 2018 | Early (fellow eye with Exudative AMD) | 88 | Healthy Fundus (fellow eye with Exudative AMD) | 58 | Superficial Capillary Plexus, Deep Capillary Plexus | Vessel Density, FAZ Area | DRI OCT Triton, software version 10.10 (Topcon Corp., Tokyo, Japan) |
Stavrev | 2018 | Early, Intermediate | 42, 47 | Healthy Controls | 66 | Superficial FAZ | FAZ Area/Perimetry/Circularity | Cirrus HD-OCT, Angioplex (Carl Zeiss Meditec, Dublin, CA, USA) |
Cicinelli | 2018 | AMD with RPD, AMD with RPD and ORA, AMD with drusen | 22, 24, 22 | Healthy Controls | 22 | Superficial Capillary Plexus, Deep Capillary Plexus | Vessel Density, FAZ Area, Retinal Layer Thicknesses | Cirrus HD-OCT 5000, Zeiss AngioPlex (Carl Zeiss Meditec, Dublin, CA, USA) |
Ahn | 2018 | Early AMD with RPD | 60 | Early AMD without RPD | 75 | Superficial Capillary Plexus, Deep Capillary Plexus | Vessel Density, Retinal Thickness, Choroidal Thickness | Cirrus HD-OCT 5000 (Carl Zeiss Meditec, Dublin, CA, USA) |
Trinh | 2019 | Intermediate | 63 | Healthy Controls | 51 | Superficial Capillary Plexus, Deep Capillary Plexus | Vessel Density/Length/Diameter/Complexity, FAZ Area/Perimetry/Circularity, Ganglion Cell Layer Thickness | Cirrus Angioplex OCTA (Carl Zeiss Meditec, Jena, Germany) |
Reiter | 2019 | Intermediate | 31 | 12 Month Follow Up | 31 | Superficial Capillary Plexus, Deep Capillary Plexus | Vessel Density, Flow Area, Drusen Volume | RTVue XR Avanti (Optovue, Fremont, CA, USA) |
You | 2020 | Geographic Atrophy | 10 | Healthy Controls | 10 | Superficial Vascular complex, Intermediate Capillary Plexus, and Deep Capillary Plexus | Vessel Density, Retinal Layer Thicknesses | RTVue XR Avanti (Optovue, Inc.) |
Lee, S | 2020 | Exudative | 142 | Non-Exudative AMD | 168 | Superficial Capillary Plexus | Vessel Density, FAZ Area/Perimetry/Circularity | Cirrus HD-OCT 5000, AngioPlex (Carl Zeiss Meditec, Dublin, CA) |
Ozcaliskan | 2020 | Intermediate | 58 | Healthy Controls | 62 | Superficial Capillary Plexus, Deep Capillary Plexus | Vessel Density, FAZ Area, Retinal Layer Thicknesses | Topcon DRI OCT Triton (Topcon Corporation, Tokyo, Japan) |
Shin | 2020 | Early, Intermediate and non-foveal Geographic Atrophy | 83 | Healthy Controls | 83 | Superficial Capillary Plexus | Vessel Density, Perfusion Density, FAZ Area/Perimetry/Circularity, Retinal Layer Thicknesses | Zeiss HD-OCT 5000 with AngioPlex (Carl Zieiss Meditec, Dublin, CA, USA) |
Vaghefi | 2020 | Intermediate | 34 | Healthy Controls (young), Health Controls (old) | 20, 21 | Superficial Capillary Plexus, Deep Capillary Plexus | Vessel Density, Retinal Thickness, FAZ Diameter | Topcon DRI OCT Triton (Topcon Corporation, Japan) |
Parisi | 2020 | Intermediate | 27 | Healthy Controls | 20 | Superficial Capillary Plexus, Deep Capillary Plexus | Vessel Density | AngioVue RTVue XR Avanti (Optovue, Fremont, CA, USA) |
Qiu | 2021 | Exudative | 30 | Healthy Fellow eye, and Healthy Control | 30, 30 | Superficial Capillary Plexus, Deep Capillary Plexus | Vessel Density, Retinal Thickness, Retinal Nerve Fibre Layer Thickness | OCTA (Optovue, Inc., Fremont, CA, USA |
Trinh | 2021 | Intermediate | 60 | Healthy Controls | 60 | Radial Peripapillary Capillary Plexus, Superficial Vascular Complex, Deep Vascular Complex | Vessel Perfusion | Cirrus HD-OCT v11.0.0.29946 Zeiss Cirrus Angioplex (Carl Zeiss Meditec; Jena, Germany) |
Can | 2022 | Exudative | 35 | Early or Intermediate AMD (fellow eye with Exudative AMD) | 35 | Superficial Capillary Plexus, Deep Capillary Plexus | Vessel Density, FAZ Area/Perimetry/Circularity | RTVue XR Avanti OCT, AngioVue (Optovue, Inc., Fremont, CA, USA) |
