Fig. 1: Changes in quantitative clinical measures by age.

Ellipsoid zone (EZ) width and proportion-preserved are reported in (a, b), retinal thickness of the whole retina (CRT), photoreceptor and retinal pigment epithelium complex (PR + RPE) and choroid are reported in (c–e). In (f), data for best corrected visual acuity (BCVA) are presented. In all subplots, patients’ data at the first visit are reported as data points and the patient ID as per Table 1 is also reported. For patients with follow-up visits, the best linear fit for quantitative measures at all visits was computed and it is reported for each patient (segments). The dashed line in (f) reports BCVA level for counting fingers.