Table 2 Cost-effectiveness of prophylactic LPI versus that of observation (base-case and scenarios with different ages at entry and exit from the cohort).

Observation period	Strategy	Cost (JPY)	Incremental cost (JPY)	QALY	Incremental QALY	ICER (JPY/QALY)
40–59 years of age (20-year horizon, base-case)	LPI	449,050	55,572	16.67	0.02	2,287,662
40–59 years of age (20-year horizon, base-case)	Observation	393,478		16.65
40–54 years of age (15-year horizon)	LPI	368,602	60,784	13.10	0.02	3,958,450
40–54 years of age (15-year horizon)	Observation	307,818		13.09
40–49 years of age (10-year horizon)	LPI	280,195	66,526	9.16	0.01	7,610,359
40–49 years of age (10-year horizon)	Observation	213,669		9.15
50–69 years of age (20-year horizon)	LPI	449,037	55,615	16.67	0.02	2,294,626
50–69 years of age (20-year horizon)	Observation	393,421		16.65
50–64 years of age (15-year horizon)	LPI	368,596	60,803	13.10	0.02	3,966,008
50–64 years of age (15-year horizon)	Observation	307,794		13.09
50–59 years of age (10-year horizon)	LPI	280,194	66,531	9.16	0.01	7,617,443
50–59 years of age (10-year horizon)	Observation	213,663		9.15
40–99 years of age	LPI	880,510	23,196	35.40	0.19	124,675
(60-year horizon)	Observation	857,314		35.21

LPI laser peripheral iridotomy, JPY Japanese Yen, QALY quality-adjusted life-year, ICER incremental cost-effectiveness ratio.

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