Fig. 1: Trial profile.

A total of 132 patients were screened and, after 38 withdrawals, a total of 94 patients were randomized to each of the treatment groups, Arm 1 (umedaptanib pegol monotherapy), Arm 2 (umedaptanib pegol + aflibercept combination therapy), and Arm 3 (aflibercept monotherapy), and subjected to clinical trials.