Fig. 1: Distribution of the relative short-term change per fluid compartment.

Each graph shows the distribution of relative responsiveness one week after intravitreal anti-VEGF injection per fluid compartment (A intraretinal fluid; B subretinal fluid; C retinal pigment epithelium detachment) in patients with neovascular age-related macular degeneration with incomplete response to anti-VEGF (intra- and/or subretinal fluid at 1 month after repetitive intravitreal anti-VEGF injection). Only eyes with a corresponding abnormal fluid compartment are shown. The relative short-term response 1 week after injection of anti-VEGF is calculated based on a fluid compartment measurement using a specifically developed and fully automated algorithm. A shows 15 study eyes with intraretinal fluid present at baseline (1 month after last injection) in the order of their percent of resolution 1 week after anti-VEGF injection as compared to baseline. The graph shows that most cases show more than 50% resolution of intraretinal fluid, but some eyes show no short-term response at all. B shows the short-term resolution distribution for subretinal fluid for the 33 eyes in which it was present at baseline. C shows the relative change distribution for the associated pigment epithelium detachment present in all study eyes.