Table 1 Measurements from spectral domain optical coherence tomography for all study time points during the evaluated refractoriness to monthly anti-VEGF for neovascular age-related macular degeneration.

From: Short-term response to anti-VEGF as indicator of visual prognosis in refractory age-related macular degeneration

 

Baseline

1 week after injection

P value

1 month after injection

P value

Clinical data

Time interval from last injection (days ± SD)

31 ± 3

7 ± 1

<0.0001

30 ± 4

0.33

Mean corrected visual acuity Snellen (letters ETDRS ± SD)

20/35 (71 ± 13)

20/35 (71 ± 13)

0.28

20/34 (72 ± 14)

0.72

OCT data from spectralis

CRT (µm ± SD)

442 ± 129

390 ± 129

<0.0001

433 ± 134

0.12

Maximum distance ILM – RPE (mean value in µm ± SD)

367 ± 61

300 ± 72

<0.0001

339 ± 79

0.0005

maximum elevation of RPE (mean value in µm ± SD)

262 ± 133

233 ± 134

<0.0001

254 ± 136

0.01

OCT data from AI algorithm

Mean volume of intraretinal cystoid spaces (µm3 ± SD)

77 ± 167

29 ± 80

0.007

65 ± 153

0.10

Mean volume of subretinal fluid (µm3 ± SD)

173 ± 250

96 ± 203

<0.0001

203 ± 418

0.58

Mean volume of pigment epithelium detachment (µm3 ± SD)

989 ± 990

906 ± 948

<0.0001

976 ± 997

0.31

  1. SD standard deviation, CRT central retinal thickness, ILM internal limiting membrane, RPE retinal pigment epithelium.
  2. p value is calculated as paired t-test.
Back to article page