Table 2 Univariate factor analysis for factor associations with the responsiveness of refractory exudative fluid at 1 week after injection.

From: Short-term response to anti-VEGF as indicator of visual prognosis in refractory age-related macular degeneration

  

Responsiveness of the refractory fluid (IRF + SRF)

Continuous variables

Mean (SD)

Correlation (p value)

Age

78.5 years (6.1)

r 0.22 (p = 0.15)

Combined baseline volume of IRF + SRF

248 µm3 (276)

r −0.43 (p = 0.003)

PED volume at baseline

989 µm3 (990)

r −0.40 (p = 0.007)

Subfoveal choroidal thickness

170 µm (65)

r −0.11 (p = 0.48)

Feeder vessel diameter on ICGA

129 µm (52)

r 0.04 (p = 0.79)

Visual acuity in logMAR

0.24 (0.23)

r −0.09 (p = 0.004)

CRT change at initiation of anti-VEGF treatment

−84 µm (148)

r 0.14 (p < 0.0001)

Systolic blood pressure

140 mmHg (20)

r 0.05 (p = 0.72)

Diastolic blood pressure

78 mmHg (11)

r 0.10 (p = 0.52)

Categorical variables

n

Mean (SD)

Anova p value

Sex

Females 29

Males 12

0.66 (0.06)

0.67 (0.10)

p = 0.92

Macular neovascularization type

Type 1 = 36

Type 2 = 8

0.65 (0.06)

0.75 (0.11)

p = 0.40

PCV on ICGA

Present = 7

Absent = 38

0.66 (0.06)

0.74 (0.13)

p = 0.56

Inflammatory signs on fluorescein angiography

Present = 5

Absent = 40

0.66 (0.05)

0.74 (0.15)

p = 0.60

Vitreomacular adherence on OCT

Present = 7

Absent = 38

0.84 (0.13)

0.64 (0.05)

p = 0.14

Dryness achieved after initial loading dose

Yes 15 (33%)

No 30 (67%)

0.68 (0.06)

0.77 (0.04)

p = 0.25

Fibrosis

Present = 4

Absent = 41

0.76 (0.12)

0.74 (0.04)

p = 0.89

Atrophy

Present = 6

Absent = 39

0.74 (0.10)

0.74 (0.04)

p = 0.98

  1. SD standard deviation, r Pearson correlation coefficient, IRF intraretinal fluid, SRF subretinal fluid, PED pigment epithelium detachment, CRT central retinal thickness, ICGA indocyanine green angiography, PCV polypoidal choroidal vasculopathy.