Fig. 1: Directed acyclic graphs of the mediation analysis with Mendelian randomization *. | Eye

Fig. 1: Directed acyclic graphs of the mediation analysis with Mendelian randomization *.

From: Intraocular pressure, primary open-angle glaucoma and the risk of retinal vein occlusion: A Mendelian randomization mediation analysis

Fig. 1

* The indirect effect of intraocular pressure (IOP) on retinal vein occlusion (RVO) can be calculated by multiplying α times β, where α is the effect of IOP on primary open-angle glaucoma (POAG), and β the effect of POAG on RVO. The proportion mediated can be estimated by dividing the indirect effect by the total effect of IOP on RVO. All estimates are shown as the difference in the logarithm of odds of the outcome, per 1 unit increase of the exposure (continuous variables: IOP) or between the two exposure groups (binary variables: POAG).

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