Abstract
Objective
To assess clinical factors leading to recurrent retinal detachment (RD) and characteristics of recurrence in patients with Stickler Syndrome.
Methods
Retrospective case series study of patients with clinical diagnosis of Stickler Syndrome who underwent rhegmatogenous RD repair. Recurrent RD after initial surgery was categorized as “early” if the recurrence was within 1 year or “late” if greater than 1 year.
Results
Thirty eyes from 22 patients underwent rhegmatogenous RD repair. For initial repair, 13 eyes underwent pars plana vitrectomy combined with scleral buckling (PPV/SB), 16 eyes underwent primary scleral buckling (SB), and 1 eye underwent pneumatic retinopexy (PnR). Recurrent RD occurred in 6 (46%) PPV/SB eyes (5 early and 1 late), 10 (63%) SB eyes (3 early and 7 late), and 0 (0%) PnR eyes (p = 0.61). PPV/SB was preferred for eyes presenting with total detachment (82%), giant retinal tears (100%), and proliferative vitreoretinopathy (PVR) (80%). For eyes with early recurrent RD, 6 (75%) had PVR leading to recurrence. For eyes with late recurrent RD, 7 (87.5%) developed a new retinal break leading to recurrence, including 4 with a break posterior to the buckle indentation apex. At last follow-up, median LogMAR visual acuity was 0.68 for eyes with recurrent RD compared to 0.29 for eyes without recurrence (p = 0.27).
Conclusions
Early recurrent RD was mostly caused by PVR, while late recurrent RD was mostly due to new retinal breaks. Eyes with seemingly uncomplicated rhegmatogenous RD repair with primary SB remained at high risk for late re-detachment.
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Data availability
The data that supports the findings of this study are available from the corresponding author upon reasonable request.
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Funding
This work was supported by NIH CORE Grant P30 EY08098 to the Department of Ophthalmology, the Eye and Ear Foundation of Pittsburgh, the Children’s Foundation, and an unrestricted grant from Research to Prevent Blindness, New York, NY.
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Conception and design: THC, MF, KKN, and JNM. Data Collection: THC, MA, HLS, and KST. Analysis and interpretation: THC, MF, MA, HLS, KST, KKN, and JNM. Overall Responsibility: THC, MF, MA, HLS, KST, KKN, and JNM.
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Chen, T.H., Fooladi, M.I., Alabek, M. et al. Recurrent retinal detachment in Stickler Syndrome. Eye 39, 170–174 (2025). https://doi.org/10.1038/s41433-024-03402-9
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DOI: https://doi.org/10.1038/s41433-024-03402-9
