Fig. 3: Examples of inflammatory response around the cortical injection sites. | Gene Therapy

Fig. 3: Examples of inflammatory response around the cortical injection sites.

From: Double viral vector technology for selective manipulation of neural pathways with higher level of efficiency and safety

Fig. 3

a, b The injection site of retrograde AAVDJ-CTb-Cre combined with anterograde AAVDJ exhibited perikarya-like structures. c, d The perikarya-like structures were found also around the injection site of retrograde AAV1-CTb-Cre combined with anterograde AAVDJ. e, f The injection site of retrograde rAAV2retro-CTb-Cre combined with anterograde AAVDJ did not exhibit any perikarya-like structure (arrowhead). Scale bar = 500 µm in (e) (applies to a, c); 100 µm in (f) (applies to b, d).

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