Fig. 3: Effect of AAV2 gene transfer on visual acuity and RGC in ONC. | Gene Therapy

Fig. 3: Effect of AAV2 gene transfer on visual acuity and RGC in ONC.

From: Rescue of retinal ganglion cells in optic nerve injury using cell-selective AAV mediated delivery of SIRT1

Fig. 3

OKR recordings demonstrate significantly decreased visual acuity in eyes of ONC mice treated with AAV2-CAG.eGFP (n = 10; experiments performed in tripicate). Treatment with AAV2- Mice treated with AAV2-CAG.SIRT1 (n = 12; experiments performed in tripicate) show no significant effect on A visual acuity or B RGC survival by day 7. C Representative RGC counts by nuclear BRN3A staining. Data represented as mean ± SEM. *P < 0.05, **P < 0.01 by 1-way ANOVA with Tukey’s HSD post-test.

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