Fig. 4: NT-3 gene transfer improves myelin thickness in Cx32 KO peripheral nerves.
From: AAV1.NT-3 gene therapy for X-linked Charcot–Marie–Tooth neuropathy type 1
G ratios calculated for the sciatic nerve of the treated and untreated mice shown as scatterplots against respective axon diameters. Lines indicate linear regression (a–c). The slopes are significantly different between the two groups, for genders combined (a; NT-3, r2 = 0.150; UT, r2 = 0.0074; Linear regression, p < 0.0001), for females (b; NT-3, r2 = 0.098; UT, r2 = 0.0106; Linear regression, p < 0.0001) and for males (c; NT-3, r2 = 0.206; UT, r2 = 0.0028; Linear regression, p < 0.0001). G-ratios shown as percent distribution indicate a shift to the left with an increase in the number of axons with thicker myelin with NT-3 treatment in genders combined (d), in females (e) and in males (f) without gender influence.
