Table 1 Electrophysiological analysis of the sciatic nerve at the end point.

From: AAV1.NT-3 gene therapy for X-linked Charcot–Marie–Tooth neuropathy type 1

Cohorts

n

Latency (ms)

Amp (mV)

CV (m/s)

Untreated

14

0.86 ± 0.03

39.96 ± 1.17

35.21 ± 1.01

NT-3 Treated

12

0.62 ± 0.02****

45.28 ± 1.27**

42.58 ± 1.01****

Wild type

6

0.58 ± 0.03††††

45.98 ± 0.72†

50.67 ± 1.24††††

  1. Data represented as mean ± SEM.
  2. **p ≤ 0.01, ****p ≤ 0.0001 between NT-3 treated and untreated group at the end point.
  3. †p ≤ 0.05, ††††p ≤ 0.0001 between WT and untreated group at the end point, One-way ANOVA with Tukey’s multiple comparisons test.
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