Fig. 4: Mouse brain distribution of the IONIS 486178 ASO.

Distribution of the ASO in the DMSXL mouse brain 1, 3, and 12 weeks after a 75 μg i.c.v. bolus injection. The ASO was visualized by immunostaining with an anti-ASO antibody (6651 Pan ASO) followed by counterstaining with hematoxylin. The scale bar of all images is shown on bottom right image.