Fig. 6: Behavioral abnormality correction of DMSXL mice after an IONIS 486178 ASO treatment. | Gene Therapy

Fig. 6: Behavioral abnormality correction of DMSXL mice after an IONIS 486178 ASO treatment.

From: Antisense oligonucleotides as a potential treatment for brain deficits observed in myotonic dystrophy type 1

Fig. 6: Behavioral abnormality correction of DMSXL mice after an IONIS 486178 ASO treatment.

RT-qPCR hDMPK (A) and Aif1 and Gfap (B) mRNA analysis of the brain. Schematic zones in the open field arena (C) and representative traces of mouse movement (D). Total distance traveled (E), time mobile (F), and average speed (G) of DMSXL homozygote mice. Number of entries into the zone (H) and duration of visit in the zone (I) of the open field arena. The statistical analyses were performed using a standard two-tailed unpaired Student’s t-test for A and B, an ordinary one-way ANOVA with Tukey’s multiple comparisons test for F. a Brown–Forsythe ANOVA test with Games-Howell’s multiple comparisons test for E and G and an ordinary two-way ANOVA with Tukey’s multiple comparisons test for H and I. The error bars are presented as the mean ± SEM for A and B or ± SD for E–I.

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