Table 1 Transgene mRNA expression was found in the myocardium of all AAV2-VEGF-B186 transduced animals and three AAV2-GFP-transduced animals.

From: AAV2-VEGF-B gene therapy failed to induce angiogenesis in ischemic porcine myocardium due to inflammatory responses

 

GFP/HPRT

VEGF-B186/HPRT

 

Transgene

GT area mean

Post. wall

GT area mean

Post. wall

Lung

Liver

Spleen

Kidney

Proximal lymph node

Pig 1

VEGF-B186

ND

ND

110.7

1.1

ND

1.0

ND

ND

ND

Pig 2

ND

ND

27

ND

ND

ND

ND

ND

ND

Pig 3

ND

ND

26.9

ND

ND

ND

ND

ND

ND

Pig 4

ND

ND

66.9

ND

ND

ND

ND

ND

ND

Pig 5

GFP

ND

ND

ND

ND

 

Pig 6

5.0

ND

ND

ND

Pig 7

2.0

ND

ND

ND

Pig 8

16.9

ND

ND

ND

  1. Gene therapy (GT) area mean consists of three independent samples from each myocardium. Results are presented as the quantity of the transgenic mRNA divided by the quantity of the HPRT mRNA.
  2. ND not detected.
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