Table 1 TIDE efficiencies of normal and pathogenic AMD-related SNPs of the complement cascade in 1-month transduced ARPE-19 cells.

From: CRISPR targeting of SNPs associated with age-related macular degeneration in ARPE-19 cells: a potential model for manipulating the complement system

SNP

Editing rate

CFB rs641153 guide 2-Wild type

9.10%

CFB rs641153-guide 2-Pathogenic

23.80%

CFB rs641153-guide 3-Wild type

11.90%

CFB rs641153-guide 3-Pathogenic

13.50%

CFB rs641153-guide 1-rv -Wild type

17.30%

CFB rs641153-guide 1-rv-Pathogenic

3.40%

CFB rs541862-guide 1-Wild type

3%

CFB rs541862-guide 1-Pathogenic

3.40%

CFB rs541862-guide 2-Wild type

3.10%

CFB rs541862-guide 2-Pathogenic

3.20%

CFB rs541862-guide 3-Wild type

31.20%

CFB rs541862-guide 3-Pathogenic

36.70%

CFH rs1410996-guide 2-Wild type

33.8%

CFH rs1410996-guide 2-Pathogenic

23.50%

CFH rs1061170-guide 1-Wild type

35.50%

CFH rs1061170-guide 1 Pathogenic

34.70%

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