Fig. 3: Anti-amyloid CARs promote selective Aβ42 phagocytosis in primary mouse microglia. | Gene Therapy

Fig. 3: Anti-amyloid CARs promote selective Aβ42 phagocytosis in primary mouse microglia.

From: Expression of anti-amyloid CARs in microglia promotes efficient and selective phagocytosis of Aβ1‒42

Fig. 3

A Immunocytochemistry images showing P2RY12 and IBA1 marker expression (top row). Magenta: mScarlet and CAR expression (as indicated) six days post AAV infection. B Fluorescence images showing intracellular co-localization of Aβ and lysosomes after incubation. C Flow cytometric analyses. D Summary of flow cytometric data showing fold MFI values for the mScarlet+ (CAR high) population versus the mScarlet- (CAR low) population (n = 4 per group) relative to viral control group (mScarlet). *P < 0.05.

Back to article page