Fig. 4: Evaluation of immune response to fetal scAAV9 delivery. | Gene Therapy

Fig. 4: Evaluation of immune response to fetal scAAV9 delivery.

From: Transabdominal ultrasound guided AAV9-GFP delivery in fetal pigs: a translational and minimally invasive model for in utero fetal gene therapy

Fig. 4

a Assessment of anti-AAV antibodies responses in serum of: sentinel sow and control untreated group; scAAV9-CAG-GFP injected (GA 108) neonatal and one month old piglets and relative sows. b Quantification of cytokines fold change in scAAV9-CAG-GFP injected neonatal piglets compared to untreated neonatal controls. Results are shown as mean ± SD. P-values are indicated by *<0.05; **<0.01; ***<0.001. Blue columns indicate GFP negative piglets; green columns indicate GFP positive piglets.

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