Fig. 2: SPVN06 DNA and RdCVF and RdCVFL mRNA expression in the retina of rd10/rd10 mice following SPVN06 subretinal bilateral injection. | Gene Therapy

Fig. 2: SPVN06 DNA and RdCVF and RdCVFL mRNA expression in the retina of rd10/rd10 mice following SPVN06 subretinal bilateral injection.

From: Preclinical safety and biodistribution of SPVN06, a novel gene- and mutation-independent gene therapy for rod-cone dystrophies

Fig. 2

Quantification of SPVN06 DNA (vector genome copies, qPCR) and RdCVF and RdCVFL transgene mRNA expression (RT-qPCR) in the mouse retina at Week 4 post-injection with SPVN06 at 1.0 × 108 vg/eye (N = 4 eyes). Data shown are mean ± SEM, with each point representing an individual retinal sample. qPCR quantitative polymerase chain reaction, RdCVF rod-derived cone viability factor, RdCVFL rod-derived cone viability factor long-form, RT-qPCR quantitative reverse transcription polymerase chain reaction.

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