Fig. 1: Schematic diagram of single- and dual-rAAV vector strategies for in vivo delivery of complete CRISPR components.
From: Therapeutic in vivo genome editing: innovations and challenges in rAAV vector-based CRISPR delivery
A All-in-one rAAV vector encoding a hypercompact mini-Cas9 along with its gRNA. B Dual-rAAV vector system encoding SaCas9 with its gRNA and a donor template, delivered separately by two vectors.
