Fig. 4: Stability changes of AAV8 under freeze-thaw and agitation stress. | Gene Therapy

Fig. 4: Stability changes of AAV8 under freeze-thaw and agitation stress.

From: Comprehensive forced degradation study revealing diverse chemical and physical degradation pathways of AAV8

Fig. 4: Stability changes of AAV8 under freeze-thaw and agitation stress.

A In vitro protein expression (n = 3). B Average hydrodynamic diameter (n = 5, technical replicates). C Recovery of monomeric AAV8 measured by SE-UPLC (n = 1). D Normalized vector genome titer (n = 4, technical replicates). E The VP ratios remained unchanged after freeze-thaw cycles and agitation stress (n = 2, technical replicates).

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