Fig. 2: Spatial transcriptomics reveals differential gene expression in rAAV2- and rAAV9-CMV-EGFP-treated mice livers per zone. | Gene Therapy

Fig. 2: Spatial transcriptomics reveals differential gene expression in rAAV2- and rAAV9-CMV-EGFP-treated mice livers per zone.

From: Spatial transcriptomics and single-nucleus RNA sequencing reveal rAAV2- and rAAV9-specific transduction signatures in the mouse liver

Fig. 2: Spatial transcriptomics reveals differential gene expression in rAAV2- and rAAV9-CMV-EGFP-treated mice livers per zone.The alternative text for this image may have been generated using AI.

a Differential gene expression in treated versus control animals, categorized by liver zone and sex in the spatial transcriptomics (ST) data. Displayed is a selection of genes related to lipid metabolism, circadian rhythm, and immune modulation. p-values were calculated using the Wald statistical test (Methods). Spatial mapping of Srebf1 gene expression across the liver of b a male rAAV2-CMV-EGFP-treated animal, c a male control animal, d a female rAAV2-CMV-EGFP-treated animal and e a female control animal. Spatial mapping of Gadd45g gene expression across the liver of f a male rAAV9-CMV-EGFP-treated animal, g a male control animal, h a female rAAV9-CMV-EGFP-treated animal and i a female control animal. The color bar indicates the level of normalized expression.

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