Fig. 4: Structural and functional relationships among AAV serotypes. | Gene Therapy

Fig. 4: Structural and functional relationships among AAV serotypes.

From: Environmental and developmental factors shape anti-AAV immunity in pigs

Fig. 4: Structural and functional relationships among AAV serotypes.The alternative text for this image may have been generated using AI.

A Heatmap of pairwise capsid sequence identity (AAV1–AAV10). Amino-acid identities were computed with Clustal Omega across full-length VP1/VP2/VP3 and displayed with hierarchical clustering. B Heatmap of pairwise Pearson correlations among anti-AAV IgG ELISA signals across serotypes for 6-week-old pigs from the High Biosecurity Facility cohort. C Same correlation matrix for the Standard Facility cohort. For (B, C), tiles show Pearson’s r; serotype order and color scale are consistent across panels.

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