Table 1 Loci with significant or suggestive associations (P < 10−6) in the EoE Immunochip analysisa

From: Genetic variants at the 16p13 locus confer risk for eosinophilic esophagitis

Chr. band rsID

Nearest gene(s)

Position (bp)

MAF cases

MAF controls

Pcombined analysis

ORcombined analysis

P Local

OR local

P external

OR external

5q23 rs4240384

intergenic

124291402

0.134

0.182

1.51E-07

0.698

0.000543

0.7166

1.32E-07

0.390

6p21 rs599707

C6orf48, HSPA1B

31808436

0.0711

0.114

3.22E-09

0.591

7.68E-05

0.6083

0.00284

0.565

7p15 rs11495981

JAZF1

28177301

0.253

0.206

8.91E-07

1.308

4.32E-05

1.432

0.0332

1.261

16p13 rs12924112

DEXI, CLEC16A

11219720

0.301

0.360

1.12E-07

0.763

0.00235

0.7912

0.00316

0.735

  1. chr. band cytogenetic band, MAF minor allele frequency across cases or controls, nearest gene gene spanning or flanking ( Mb away from) the index variant, OR odds ratio for the minor allele, rsID reference sequence identification number of the variant
  2. aThe most highly associated variant is shown for each locus. Position is given relative to Build 37 of the reference genome
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